中枢神经细胞瘤的MRI表现特点与病理对照研究  

Central neurocytoma：MRI manifestation and clinicopathological findings

作　　者：李靖 张宏凯 姜丽娜 孙淼淼 梁盼[3] 张丹丹[4] 李辛 高剑波[3] 黎海亮 LI Jing;ZHANG Hongkai;JIANG Lina;SUN Miaomiao;LIANG Pan;ZHANG Dandan;LI Xin;GAO Jianbo;LI Hailiang(Department of Radiology;Department of Pathology,the Affiliated Cancer Hospital of Zhengzhou University, He ＇ nan Cancer Hospital, Zhengzhou 450008, China;Department of Radiology;Department of Pathology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学附属肿瘤医院(河南省肿瘤医院)放射科,河南郑州450008 [2]郑州大学附属肿瘤医院(河南省肿瘤医院)病理科,河南郑州450008 [3]郑州大学第一附属医院放射科,河南郑州450052 [4]郑州大学第一附属医院病理科,河南郑州450052

出　　处：《实用放射学杂志》2018年第4期501-504,525,共5页Journal of Practical Radiology

摘　　要：目的 探讨中枢神经细胞瘤（CNC）临床病理和MRI特点。方法 回顾性收集经手术病理证实为CNC患者的临床和MRI资料，患者术前接受头颅MRI平扫和增强扫描，根据部位分为侧脑室内和外2组，并比较临床病理和MRI表现特点的差异。结果 共40例患者纳入研究，肿瘤均单发，39例位于脑室系统内，包括27例位于侧脑室内，12例位于侧脑室外，其中2例位于第三脑室，5例同时累及侧脑室和第三脑室，5例累及全脑室；1例位于脑室外（左侧颞叶）。MRI上肿瘤呈T1WI等、T2WI等/稍高信号，均有囊变，5例出血，2例钙化，36例明显强化，26例瘤内见强化血管影。对比侧脑室内肿瘤，侧脑室外组患者平均年龄、肿瘤最大径和Ki-67阳性表达较高，富血供比例较低（P＜0.05），男女比例、囊性和囊实性表现比例略高，较少出现强化血管影（P＞0.05）。结论 典型CNC多位于侧脑室内，囊变坏死常见，实性部分明显强化并多见强化血管影；脑室外CNC少见，肿瘤常较大，Ki-67高表达，MRI增强呈中等强化，较少出现血管影。Objective To explore the clinical and MRI features of central neurocytoma（CNC）. Methods The clinical and MRI data of the pathologically confirmed CNC were retrospectively collected and compared,all the patients had undergone pre-surgery MRI plain and contrast enhanced scans.Patients were divided according to the location of the tumor as intra-lateral ventricle and ex-lateral ventricle group.Results Forty patients were finally enrolled, all tumors were solitary, 39 of which were located in the ventricular system,including 27 cases located in lateral ventricle and 12 in the lateral ventricle,2 in third ventricle,5 in both lateral and third ventricle and 5 involving the whole ventricles;and 1 located in exventficle （left temporal lobe）. The tumors showed iso-intense on T1WI and T2 WI with varying degrees of cystic degeneration. Hemorrhage was shown in 5 cases,calcification in 2 cases, markedly hyper-vaseular enhancements were shown in 36 cases with 26 cases presented visible enhanced vessel sign.The comparison analysis between intra-and ex-lateral ventricle groups revealed that, the patients age, tumor size and Ki-67 expression were higher in ex-lateral ventricle group （P〈0.05 ） ; hypervascular enhancement （P 〈0.05） , gender ratio, cystic/cystic-solid appearance and vessel sigh（P〉0.05） were lower than those in intra-lateral ventricle group. Conclusion CNC is typically located in lateral ventricle, with cystic and necrotic degeneration areas, hypervascular enhancement with visible vessels in solid portion on enhanced MR images;The exateral ventricle CNC is rare,it commonly presents a larger tumor with high Ki-67 expression,and moderate enhancement with less visible vessels on enhanced MRI.

关 键 词：中枢神经细胞瘤 磁共振成像 

分 类 号：R739.4[医药卫生—肿瘤] R445.2[医药卫生—临床医学]