非肿块型乳腺癌MRI特征与VEGF、CerbB-2阳性表达相关性分析  

The relationship study of MRI feature and VEGF ＆ CerbB-2 expression in atypical breast cancer

作　　者：林华 邓德茂[1] 陈文福[1] 李敏[1] LIN Hua;DENG Demao;CHEN Wenfu;LI Min(Department of Radiology, the First Affiliated Hospital of Guangxi University of Chinese Medicine ,Nanning 530023,Chin)

机构地区：[1]广西中医药大学第一附属医院放射科,广西南宁530023

出　　处：《实用放射学杂志》2018年第4期537-540,共4页Journal of Practical Radiology

摘　　要：目的 探讨非肿块型乳腺癌MRI特征与血管内皮生长因子（VEGF）和原癌基因（CerbB-2）表达的相关性及其临床意义。方法 回顾性分析82例经病理证实的乳腺癌MRI特征，对比分析对非肿块型乳腺癌MRI特征与VEGF、CerbB-2表达的相关性。结果 82例患者中VEGF阳性表达57例（69.5%），CerbB-2阳性表达50例（61.0%）；病灶最大径≥2.0 cm时VEGF阳性表达率78.8%，最大径＜2.0 cm时VEGF阳性表达率20.4%，2组间差异有统计学意义（P＜0.05）；内部坏死、表观扩散系数（ADC）值与VEGF阳性表达呈正相关（P＜0.05）；内部强化方式、T1WI动态增强时间-信号强度曲线（TIC）与VEGF阳性表达无明显相关性（P＞0.05）；内部坏死、ADC值与CerbB-2阳性表达有关（P＜0.05），病灶最大径、内部强化方式、T1WI动态增强TIC与CerbB-2阳性表达无明显相关性（P＞0.05）。结论 非肿块型乳腺癌病灶最大径、内部坏死及ADC值与分子生物学指标（VEGF、CerbB-2）有一定相关性。Objective To explore the relationship between MRI and VEGF ＆ CerbPr2 expression in atypical breast cancer.Methods 82 cases of atypical breast cancer confirmed by pathology were analyzed retrospectively.The relationship between MRI and VEGF ＆ CerbB-2 expression were compared and analyzed.Results In total patients,57 cases were VEGF positive expression （69.5% ,57/82） ,50 cases were CerbB-2 positive expression（61.0%, 50/82）.The VEGF positive expression rate was 78.8% in maximum diameter 92.0 cm group, which was obviously higher than 〈 2.0 cm group（P〈0.05）.Internal necrosis, ADC value and VEGF positive expression were positively correlated （P〈0.05）.There were not positively correlated relationships between internal reinforcement method, TIC and VEGF positive expression （P〈0.05）.There were positively correlated relationships between internal necrosis, ADC value and CerbB-2 positive expression （P〈0.05）.There were not positively correlated relationships between maximum diameter, internal reinforcement method, TIC and CerbPr2 positive expression （P〉0.05）.Conclusion There are relationships between the maximum diameter,internal necrosis,ADC value and molecular biology （VEGF,CerbB-2） of the atypical breast cancer.

关 键 词：非肿块型乳腺癌 磁共振成像 血管内皮生长因子 CERBB-2 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]