脑白质病变合并脑微出血相关危险因素研究  

Research on relative risk factors of white matter lesions combined with cerebral microbleeds

作　　者：倪初源[1] 程小华[1] 曹毅[1] 程蛰承[2] 吴晟昊[1] 郭志浩 汪飞[1] NI Chu-yuan;CHENG Xiao-hua;CAO Yi(Department of Neurology, Huangshan City People＇s Hospital, Huangshan 245000, Chin)

机构地区：[1]黄山市人民医院神经内科,245000 [2]黄山市人民医院医学影像科,245000

出　　处：《临床神经病学杂志》2018年第2期99-102,共4页Journal of Clinical Neurology

基　　金：黄山市科技计划项目(2015Z-08)

摘　　要：目的探讨脑白质病变(WML)合并脑微出血(CMB)的相关危险因素。方法收集2014年1月~2017年6月黄山市人民神经内科住院患者中符合脑小血管病诊断,且经头颅MRI证实存在WML者94例,其中磁敏感成像(SWI)检测有CMB者59例为CMB组,无CMB者35例为非CMB组。对两组间人口学资料,高血压病史、糖尿病史、卒中史、吸烟史、饮酒史及相关血液指标进行分类、分型后进行统计分析。结果CMB组患者吸烟史、高血压病史的比例及WML严重程度评分、血UA明显高于非CMB组(均P<0.05)。单因素回归分析示血UA高、吸烟史、高血压病史及WML严重程度评分高与WML患者合并CMB密切相关(均P<0.05);进一步多因素回归分析示血UA高(OR=1.007,95%CI:1.002~1.012,P=0.009)、WML严重程度评分高(OR=1.584,95%CI:1.085~2.313,P=0.017)是WML患者合并CMB的独立危险因素。结论高血UA、重度WML为WML患者合并CMB的独立危险因素。Objective To investigate relative risk factors of white matter lesions （WML） combined with cerebral microbleeds （CMB）. Methods Ninety four patients with WML were diagnosed by MRI and susceptibility weighted imaging （SWI） and hospitalized in department of neurology of Huangshan city people＇s hospital from January 2014 to June 2017. The patients were divided into CMB group （59 cases） and non-CMB group （35 cases）. The data of demographic, history of hypertension, diabetes, stroke, drinking and blood test resuhs were classified, and then analyzed. Results The rates of smoking history and hypertension history, severity of WML and blood uric acid （UA） in CMB group were significantly higher than that of non-CMB group （ all P 〈 0.05 ）. Single factors Logistic regression analysis showed that increase of blood UA, history of smoking and hypertension, severity of WML were closely related with CMB in the patients of WML （all P 〈 0.05）. Multiple factors Logistic regression analysis showed that the blood UA （ OR = 1. 007, 95 % CI： 1. 002 - 1.012, P = 0.009） and severity of WML （ OR = 1. 584, 95 % CI： 1. 085 -2. 313, P = 0. 017） were independent risk factors for WML patients combined with CMB. Conclusion High UA and severe WML are independent risk factors for WML patients combined with CMB.

关 键 词：脑白质病变 脑微出血 尿酸 危险因素 

分 类 号：R743.9[医药卫生—神经病学与精神病学]