白细胞介素8及白细胞介素受体1信号轴在胃癌组织中的临床意义  

Clinical significance of the interleukin 8 and interleukin receptor 1 axis in stomach neoplasms

作　　者：余亮[1] 周国强[2] 余生元[2] 郭健[2] 李德春[1] Yu Liang;Zhou Guoqiang;Yu Shengyuan;Guo Jian;Li Dechun(Department of General Surgery, First Hospital Affiliated to Suzhou University, Suzhou 215006, China;Department of General Surgery ,the Second People＇s Hospital of Changshou ,Changshou 215500 ,China)

机构地区：[1]苏州大学附属第一医院普外科,215006 [2]常熟市第二人民医院普外科,215500

出　　处：《中华老年医学杂志》2018年第4期427-430,共4页Chinese Journal of Geriatrics

基　　金：江苏省卫生厅医改试点单位科研课题（YG201406）,常熟市科技发展计划（CS201504）

摘　　要：目的探讨反映胃癌发生、发展和转移的敏感指标，为胃癌的早期诊断及治疗、病程监控提供客观依据。方法收集108例胃癌患者临床资料，通过免疫组化检测白细胞介素受体1（CXCR1）在胃癌及其癌旁组织标本中的表达情况；对胃癌患者5年生存率进行Logistic回归分析，将胃癌患者临床病理学资料结合CXCR1的表达情况进行相关性分析。结果与对应的癌旁组织相比，CXCR1在胃癌组织中表达阳性率明显较高；CXCR1表达水平与肿瘤分化程度（P＝0.017）、TNM分期（P＝0.006）和是否有淋巴结转移（P＝0.035）呈显著相关；CXCR1阳性患者相比阴性患者其总生存率较低（P＝0.043），无复发生存率也更短（P＝0.029）。结论CXCR1在胃癌组织中表达上调，与肿瘤分化程度、TNM分期和淋巴结转移呈显著相关，CXCR1阳性与患者不良预后显著相关，有可能成为临床上预后判断的指标之一。ObjectiveTo explore sensitive indicators for the initiation, development, and metastasis of gastric cancer and to provide objective evidence for the early diagnosis, treatment, and progression monitoring of gastric cancer.MethodsA total of 108 patients with gastric cancer were enrolled in this study.The expression of interleukin receptor 1（CXCR1）in samples from gastric cancer and adjacent tissues was detected by immunohistochemistry and patient clinical data were collected for correlation analysis.Logistic regression analysis of the 5-year survival rate of patients was conducted.ResultsThe positive CXCR1 expression rate in gastric neoplasm tissues was significantly higher than that in adjacent tissues.Nevertheless, CXCR1 was correlated with tumor differentiation （P=0.017）, TNM staging （P=0.006）, and the existence of lymphatic metastasis （P=0.035）. The overall survival rate （P=0.043） and recurrence-free survival rate （P=0.029） of patients with positive CXCR1 were lower than those of patients with negative CXCR1.ConclusionsCXCR1 expression levels increase in gastric neoplasm tissues and are associated with tumor differentiation, TNM staging, and lymphatic metastasis.Positive CXCR1 is correlated with poor prognosis and has the potential to serve as one of clinical prognostic indicators.

关 键 词：胃癌 CXCL8/CXCR1 肿瘤分化程度 

分 类 号：R735.2[医药卫生—肿瘤]