术前动脉灌注新辅助化疗联合手术治疗对早中期宫颈癌患者血管内皮生长因子及预后的影响  

The vascular endothelial growth factor and prognosis in early and middle stage cervical cancer treated by preoperative neoadjuvant intraarterial infusion chemotherapy combined with surgery

作　　者：闫文静 窦娴静 翟垚青 YAN Wenjing;DOU Xianjing;ZHAI Yaoqing(Department of Pathology;Department of Gynecology, Maternal and Child Health Hospital of Jiaozuo City, Jiaozuo 454000, He＇nan, China)

机构地区：[1]焦作市妇幼保健院病理科,河南焦作4540000 [2]焦作市妇幼保健院妇科,河南焦作4540000

出　　处：《癌症进展》2018年第3期356-358,362,共4页Oncology Progress

摘　　要：目的探讨术前动脉灌注新辅助化疗(NACT)联合手术治疗对早中期宫颈癌患者血管内皮生长因子(VEGF)及预后的影响。方法选取118例ⅠB2~ⅡB期宫颈癌患者,根据入院时间的不同将患者分为两组,奇数日入院的患者归为对照组(n=50),偶数日入院的患者归为观察组(n=68),对照组患者直接给予根治性手术治疗,观察组患者在动脉灌注NACT结束后3周给予根治性手术治疗。比较两组患者治疗前后的VEGF水平、手术时间、术中出血量、术后住院时间、术后并发症发生率、生存率和复发率。结果观察组患者灌注化疗的平均疗程为(1.53±0.24)个,治疗有效率为61.76%(42/68)。观察组患者的手术时间及术后住院时间均短于对照组,术中出血量少于对照组,术后并发症发生率低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者的VEGF水平及复发率均明显低于对照组,差异均有统计学意义(P﹤0.01)。结论术前动脉灌注NACT联合手术治疗可明显降低早中期宫颈癌患者的VEGF水平,具有较好的治疗效果,且术后并发症发生率低。Objective To explore the effects of preoperative neoadjuvant intraarterial infusion chemotherapy combined with surgery on the vascular endothelial growth factor（VEGF） and prognosis in early and middle stage cervical cancer patients. Method 118 cases of patients with cervical cancer of stage IB2 to IIB were included in the study, they were randomized by date as control group（admitted on odd-numbered days, n=50）, or study group（admitted on even-numbered days, n=68）, the control group received radical surgery, while the study group was administered with neoadjuvant intraarterial infusion chemotherapy in 3 weeks before radical surgery. The VEGF level before and after treatment, operative time, blood loss, hospital stay, incidence of postoperative complications, survival rate and recurrence rate of the two groups were collected and compared. Result The average cycles of infusion chemotherapy in study group was（1.53 ±0.24）, the response rate was 61.76%（42/68）. Compared with control group, the operative time, post-operation hospitalization time and blood loss were less, and the incidence of postoperative complications was lower in study group, the differences were statistically significant（P〈0.05）. After treatment, the VEGF level and recurrence rate in study group were significantly lower than that in control group（P〈0.01）. Conclusion Preoperative neoadjuvant intraarterial infusion chemotherapy plus surgical treatment can significantly reduce the level of VEGF in patients with early and middle stage cervical cancer, with fair clinical efficacy and low incidence of complications.

关 键 词：早中期宫颈癌 动脉灌注新辅助化疗 根治性手术 血管内皮生长因子 预后 

分 类 号：R737.33[医药卫生—肿瘤]