肝脏原发性神经内分泌肿瘤影像学诊断与肝动脉化学治疗栓塞术治疗6例分析  被引量:10

Diagnostic imaging of primary hepatic neuroendocrine tumors and treatment with transarterial chemoembolization: analysis of 6 cases

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作  者:李小帅[1] 张孟超[1] 曲阳春[1] 张晓谦[1] 潘峰[1] 刘云霞[1] Li Xiaoshuai;Zhang Mengchao;Qu Yangchun;Zhang Xiaoqian;Pan Feng;Liu Yunxia(Department of Radiology, the Chinese-Japan Union Hospitai of Jilin University, Changchun 130033, China)

机构地区:[1]吉林大学中日联谊医院放射科,长春130033

出  处:《中华肝脏病杂志》2018年第4期294-297,共4页Chinese Journal of Hepatology

摘  要:目的探讨肝脏原发性神经内分泌肿瘤的影像学诊断、治疗及预后情况。方法回顾性分析6例经病理学证实的肝脏原发性神经内分泌肿瘤患者的临床症状、影像学表现、病理学免疫组织化学检查结果及介入治疗情况,并复习相关文献。结果6例患者均以腹痛症状就诊,且4例病灶单发,2例病灶多发。磁共振成像检查显示:T1加权成像呈低信号、T2加权成像呈高信号,边界较清楚;增强扫描病灶动脉期呈不均匀明显强化,门静脉期、平衡期呈持续性强化,周围可见环形强化的包膜。病理学均诊断为肝脏原发性神经内分泌肿瘤。6例患者经介入治疗后,近期均有一定治疗效果,其中4例患者行多次介入治疗;随访4年,效果较满意。结论肝脏原发性神经内分泌肿瘤极为少见,影像学表现具有一定特异性,最终依靠病理学免疫组织化学确诊。肝脏原发性神经内分泌肿瘤行肝动脉化疗栓塞术治疗可取得较满意效果。Objective To investigate the imaging diagnosis, treatment and prognosis of primary hepatic neuroendocrine tumors. Methods The clinical features, imaging manifestations, histopathological and immunohistochemical findings and interventional therapy of 6 patients identified with pathologically confirmed primary hepatic neuroendocrine tumors were retrospectively analyzed, and the related literatures were reviewed. Results All 6 patients presented with symptoms of abdominal pain. 4 patients had solitary hepatic mass and 2 patients had multiple hepatic masses. Magnetic resonance imaging showed low signal intensity on T 1 weighted imaging, high signal intensity on T2 weighted imaging and clear boundary; the arterial phase of enhancement scan was uneven and enhanced, and portal venous phase or delayed phase showed continuous enhancement, surrounded by ring enhanced capsule. A pathological diagnosis was primary neuroendocrine tumor of the liver. After interventional treatment, 6 patients had some therapeutic effects. Among them, 4 patients underwent multiple interventional therapies, followed by 4 years of follow-up has shown satisfactory results. Conclusion Primary hepatic neuroendocrine tumors are very rare and their imaging manifestations are specific. Eventually, relies on pathological and immunohistochemical diagnosis. Transarterial chemoembolization therapy can bring satisfactory results in the treatment of primary hepatic neuroendocrine tumor.

关 键 词:肝肿瘤 诊断 介入治疗 

分 类 号:R735.7[医药卫生—肿瘤]

 

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