替诺福韦治疗艾滋病导致的范可尼综合征回顾性分析  

Tenofovir associated Fanconi syndrome in patients with AIDS:a retrospective analysis

作　　者：夏玉朝[1] 杨萱[2] 卓晓芳 安永辉[2] 王双利[2] XIA Yu-chao;YANG Xuan;ZHUO Xiao-fang;AN Yong-hui;WANG Shuang-li(l. Department of Pharmac;Department of Infection Disease, the Sixth People＇s Hospital of Zhengzhou, Henan Zhengzhou 450000,China)

机构地区：[1]郑州市第六人民医院药学部,河南郑州450000 [2]郑州市第六人民医院感染科,河南郑州450000

出　　处：《中国医院药学杂志》2018年第6期622-625,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:分析替诺福韦(TDF)治疗艾滋病导致的范可尼综合征(FS)的影响因素和预后。方法:对2014年1月-2016年9月发生的64例TDF相关的FS进行统计、分析。结果:FS发生率为2.08%,大部分在使用TDF 2~4年内发生,主要表现为电解质紊乱、尿蛋白和尿糖高,51.56%的患者合并肾小球滤过率下降,37.50%的患者合并骨质疏松。FS好发人群以年龄大、体质量低和合并有基础疾病为主。停用TDF和对症治疗后大部分好转,4例经过1年治疗无缓解。结论:使用TDF要定期监测肾功能、尿常规和电解质,发现FS要及时治疗。OBJECTIVE To analyze the influential factor and prognosis of tenofovir associated Fanconi syndrome（FS）.METHODS Sixty four AIDS patients had tenofovir associated Fanconi syndrome from January 2014 to September 2016 were collected and analyzed.RESULTS Most patients had FS 2-4 years after starting antiretroviral treatment including tenofovir,characterized by disturbed electrolytes,urine glucose and urine protine,51.56% of patients accompanied with decrease in estimated glomerular filtration rate,37.5% of patients accompanied with osteoporosis.This was highly dependent on factors such as low body weight,older age,or preexisting basic system diseases.After TDF withdrawal and symptomatic treatment,major renal function was reverted,but 4 of them had no improvement after one year therapy.CONCLUSION The patients took tenofovirl for a long time should be monitored for renal function,urine routine and electrolyte,and visit the clinic in time when FS occurs.

关 键 词：范可尼综合征 替诺福韦 艾滋病 

分 类 号：R978.7[医药卫生—药品]