低共熔溶剂催化一锅合成4,7-二氢-1H-吡唑并[3,4-b]吡啶-5-腈衍生物（英文）  

Deep Eutectic Solvent Catalyzed One-Pot Synthesis of 4,7-Dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles

作　　者：高歌 王萍[2] 刘鹏[1] 张卫红 默丽萍[1] 张占辉[1] Gao Ge;Wang Ping;Liu Peng;Zhang Weihong;Mo Liping;Zhang Zhanhui(National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024;Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050026)

机构地区：[1]河北师范大学化学与材料科学学院化学国家级实验教学示范中心,石家庄050024 [2]河北化工医药职业技术学院化学与环境工程系,石家庄050026

出　　处：《有机化学》2018年第4期846-854,共9页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.21272053);the Natural Science Foundation of Hebei Province(No.B2015205182)~~

摘　　要：首次发现脯氨酸和草酸形成的低共熔溶剂可作为一种有效的制备4,7-二氢-1H-吡唑并[3,4-b]吡啶-5-甲腈衍生物的催化剂,该方法用醛、3-氧代丙腈和1H-吡唑-5-胺为原料,一锅法高效地合成该类化合物.方法具有底物适用范围广、操作简便、催化剂可回收利用及达到克级规模的合成等优点.Deep eutectic solvent based on L-proline and oxalic acid has been demonstrated for the first time as an efficient catalyst for synthesis of 4,7-dihydro-lH-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives via one-pot three-component reaction of aldehyde, 3-oxopropanenitrile and 1H-pyrazol-5-amine. The key features of this approach include the broad substrate scope, operational simplicity, recyclable catalyst and possibility to scale up giving multigram quantities.

关 键 词：低共熔溶剂 多组分反应 4 7-二氢-1H吡唑并[3 4-6]吡啶-5-腈 绿色化学 

分 类 号：O626[理学—有机化学]