急性缺血性脑卒中患者外周循环血小板微颗粒和内皮细胞微颗粒水平的研究  

Peripheral Blood Platelet Microparticles and Endothelial Microparticles in Patients with Acute Ischemic Stroke

作　　者：周森林 ZHOU Senlin(Department of Neurology,Wuzhou People＇s Hospital,Wuzhou Guangxi 543000,Chin)

机构地区：[1]梧州市人民医院神经内科,广西梧州543000

出　　处：《解放军预防医学杂志》2018年第3期336-338,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：广西壮族自治区梧州市科技厅项目(No.201502030)

摘　　要：目的探讨急性缺血性脑卒中患者外周循环血小板微颗粒(PMPs)和内皮细胞微颗粒(EMPs)的表达水平及与疾病发生和进展的关系。方法选择2016年6月-2017年6月于我院首次诊断急性缺血性脑卒中患者80例作为观察组,另取80例健康体检者作为对照组,观察组于入院24 h和治疗后1 d、7 d、14 d以及随访1个月、3个月和6个月时,采用流式细胞术检测循环PMPs和EMPs水平,采用美国国立卫生研究院卒中量表(NIHSS)进行神经功能缺损评分;以对照组循环PMPs和EMPs水平为参照。结果观察组PMPs和EMPs水平在不同性别、年龄、身体质量指数(BMI)、吸烟、脑血管病家族史间比较均无差异(P>0.05)。大面积脑梗死、平均收缩压(mSBP)≥160 mmHg、平均舒张压(mDBP)≥100 mmHg、空腹血糖(FBP)≥10.0 mmol/L、NIHSS≥10分患者的PMPs和EMPs水平明显升高,差异有统计学意义(P<0.05)。观察组PMPs和EMPs水平于治疗后7 d达高峰,治疗后14 d开始回落,随访6个月时仍高于对照组(P<0.05)。结论急性缺血性脑卒中早期检测外周循环PMPs和EMPs水平对评估疾病严重程度和临床预后有重要的参考价值。Objective To investigate the correlations between the expression levels of circulating platelet microparticles（ PMPs） and endothelial microparticles（ EMPs） and the occurrence and progression of disease in patients with acute ischemic stroke（ AIS）.Methods A total of 80 cases who were diagnosed with AIS for the first time in our hospital between June 2016 and June 2017 were enrolled as the observation group,while another 80 healthy persons served as the control group. The levels of PMPs and EMPs were detected by flow cytometry at 24 h after hospitalization,1 d,7 d,14 d after treatment and during follow-up after 1 month,3 months and 6 months. The National Institutes of Health Stroke Scale（ NIHSS） was used to evaluate the neurological deficit score. The levels of circulating PMPs and EMPs in the control group were referred to. Results The levels of PMPs and EMPs were not significantly different between patients who were different in gender,age,body mass index（ BMI）,smoking history,family history of cerebrovascular diseases（ P〉0.05）. The levels of PMPs and EMPs in patients with large-area cerebral infarction,mean systolic blood pressure（ mSBP） ≥160 mmHg,mean diastolic blood pressure（ mDBP） ≥100 mmHg,fasting blood glucose（ FBP） ≥10.0 mmol/L,NIHSS score ≥10 were significantly increased（ P〈 0. 05）,with statistically significant difference. The levels of PMPs and EMPs in the observation group reached the peak at 7 d after admission,and began to fall at 14 d,but remained higher than those of the control group during follow-up after 6 months（ P〈0.05）.Conclusion Early detection of levels of peripheral circulating PMPs and EMPs in case of acute ischemic stroke is of great value for assessing the severity and prognosis of the disease.

关 键 词：急性缺血性脑卒中 血小板微颗粒 内皮细胞微颗粒 

分 类 号：R743[医药卫生—神经病学与精神病学]