雷替曲塞用于腹腔镜结直肠癌根治术中腹腔灌注化疗的安全性研究  

Security observation of intraperitoneal perfusion chemotherapy with Raltitrexed in laparoscopic radical operation for colorectal cancer

作　　者：张洋[1] 陈志康[1] 郭雄[1] 王雯[1] ZHANG Yang;CHEN Zhikang;GUO Xiong;WANG Wen(Colorectal Surgical Department, Hepatobiliary and Enteric Surgery Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China)

机构地区：[1]中南大学湘雅医院肝胆肠外科研究中心结直肠肛门外科

出　　处：《中国临床药理学与治疗学》2018年第3期313-318,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：湖南省自然科学基金(2017JJ3502)

摘　　要：目的:观察及评估雷替曲塞用于腹腔镜结直肠癌根治术中腹腔灌注化疗对术后并发症及不良反应、术后恢复、系统毒性等的影响。方法:分析81例结直肠癌患者的临床数据:术中雷替曲塞腹腔灌注组(A组)41例;常规手术对照组(B组)40例。分析比较两组患者术前一般情况、手术时间、术后并发症及不良反应、肠道功能恢复时间、术前及术后3 d的血常规、肝肾功能。结果:两组患者间一般情况比较,差异无统计学意义(P>0.05)。两组患者术后并发症及不良反应、手术时间及肠道功能恢复时间比较,差异均无统计学意义(P>0.05);两组患者间术前、术后白细胞计数(WBC)、血小板(PLT)、AST、ALT、Cr、BUN比较,差异均无统计学意义(P>0.05)。结论:雷替曲塞用于腹腔镜结直肠癌根治术中腹腔灌注化疗具有良好的患者耐受性和安全性。AIM： To observe and evaluate the postoperative complication and adverse reaction,postoperative recovery and systemic toxicity of intraperitoneal perfusion chemotherapy with raltitrexed in laparoscopic radical operation for colorectal cancer.METHODS： The clinical data of 81 patients with colorectal cancer were analyzed. Group A underwent laparoscopic radical operation ＋ intraperitoneal perfusion with Raltitrexed; Group B just underwent laparoscopic radical operation. General information,operative time,postoperative complication and adverse reaction,the recovery time of the bowel function,routine blood tests as well as liver and kidney functions before and 3 days after operation between the two groups were evaluated and compared. RESULTS： No statistically significant difference were observed with general information（ P〈0. 05）. No statistically significant difference were observed with postoperative complication and adverse reaction,the recovery time of the bowel function and operative time（ P 0. 05）; No statistically significant difference were observed with WBC,PLT,AST,ALT,Cr and BUN before and 3 days after operation（ P 0. 05）. CONCLUSION： Intraperitoneal perfusion chemotherapy with Raltitrexed in laparoscopic radical operation for colorectal cancer is safe and well tolerated to patient.

关 键 词：结直肠癌 雷替曲塞 腹腔镜根治术 腹腔灌注 

分 类 号：R735.3[医药卫生—肿瘤]