艾迪注射液对培美曲塞联合奈达铂治疗晚期非小细胞肺癌的增效作用  

Synergistic effect of Addie injection on pemetrexed combined with nedaplatin in the treatment of advanced non-small cell lung cancer

作　　者：李伟文[1] 黎媛[1] 孙蕾[1] 黄公才 赵中伟[3] LI Weiwen;LI Yuan;SUN Lei;HUANG Gongcai;ZHAO Zhongwei(Department of Respiratory Medicine, Lishui Central Hospital, Lishui 323000, Zhejiang , China;Department of Medicine, Qingtian People＇s Hospital, Lishui 323999, Zhejiang, China;Radiological Department, Lishui Central Hospital, Lishui 323000, Zhejiang, China)

机构地区：[1]丽水市中心医院呼吸内科 [2]青田县人民医院内科 [3]丽水市中心医院放射科

出　　处：《中国临床药理学与治疗学》2018年第3期325-328,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省科技计划项目(2014C33147)

摘　　要：目的:探讨艾迪注射液对培美曲塞联合奈达铂治疗晚期非小细胞肺癌是否有增效作用。方法:将86例晚期非小细胞肺癌患者分为研究组和对照组,每组43例。对照组采用培美曲塞联合奈达铂治疗。研究组在对照组基础上,给予艾迪注射液治疗。对比两组的临床疗效,并检测两组患者治疗前后血清免疫指标变化,包括CD3_+、CD4_+、CD4_+/CD8_+、Ig M、Ig A、IgG,观察治疗过程中两组患者不良反应的发生情况。结果:研究组的控制率及有效率高于对照组,但差异无统计学意义(P>0.05);对照组治疗后的CD3_+、CD4_+、CD4_+/CD8_+、Ig A、IgG较治疗前均明显降低(P<0.05);研究组治疗后的CD3_+、CD4_+、CD4_+/CD8_+、Ig A、IgG明显高于对照组,差异有统计学意义(P<0.05);研究组胃肠道反应、白细胞减少、肝肾功能异常的发生程度明显低于对照组,差异有统计学意义(P<0.05)。结论:艾迪注射液对培美曲塞联合奈达铂治疗晚期非小细胞肺癌具有增效减毒的作用。AIM： To investigate whether Addie injection can improve the efficacy of pemetrexed combined with nedaplatin in the treatment of advanced non-small cell lung cancer. METHODS：Eighty-six cases of advanced non-small cell lung cancer patients were divided into the study group and the control group,43 cases in each group. The control group was treated with pemetrexed combined with nedaplatin. The study group was treated with Addie injection on the basis of the control group.The clinical efficacy of the two groups was compared. The changes of serum immune indexes before and after treatment in two groups were detected. The immune indexes included CD3_＋,CD4_＋,CD4_＋/CD8_＋,Ig M,Ig A,IgG. Adverse reactions of two groups in the course of treatment were observed.RESULTS： The control rate and effective rate of the study group were higher than those of the control group. But the difference was not statistically significant（ P〈0. 05）. The levels of CD3_＋,CD4_＋,CD4_＋/CD8_＋,Ig A and IgG in the control group were significantly decreased after treatment（ P 0. 05）. The levels of CD3_＋,CD4_＋,CD4_＋/CD8_＋,Ig A and IgG after treatment in the study group were significantly higher than those in the control group.The difference was statistically significant（ P 0. 05）. The incidence of gastrointestinal reaction,white blood cell reduction,abnormal liver and kidney function in the study group was significantly lower than that in the control group. The difference was statistically significant（ P 0. 05）. CONCLUSION： Addie injection has a synergistic and attenuated effect on pemetrexed combined with nedaplatin in the treatment of advanced non-small cell lung cancer.

关 键 词：艾迪注射液 培美曲塞 奈达铂 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]