针刺联合肠炎清治疗大肠湿热证活动期溃疡性结肠炎临床价值分析  

Clinical Value of Acupuncture Combined with Changyanqing Decoction in Treatment of Ulcerative Colitis of Large Intestine Damp-Heat Syndrome

作　　者：丛龙玲 吕永慧 詹原泉 CONG Longling;ZHAN Yuanquan;LYU Yonghui(Spleen and Stomach Department, Guangzhou Hospital of TCM Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510130, Guangdong, China)

机构地区：[1]广州中医药大学附属广州中医院广州市中医医院脾胃科

出　　处：《辽宁中医杂志》2018年第4期811-815,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：广州市中医药科技项目(20172A010004)

摘　　要：目的：分析针刺联合肠炎清治疗大肠湿热证活动期溃疡性结肠炎的临床价值。方法：选择2014年5月—2016年7月在本院诊断为溃疡性结肠炎,并处于大肠湿热证活动期的患者共147例,按照入组顺序随机均分为两组,分组方法依据随机数字表法。入组后对照组口服美沙拉嗪肠溶片;同时观察组给予针刺联合肠炎清治疗。观察两组患者临床疗效,并对两组患者治疗前后中医证候进行积分比较。检测患者治疗前后血清免疫球蛋白（Ig A、Ig G、Ig M）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）的水平。采用黏膜病变活动指数、Baron评分和Geboes指数评价结肠黏膜病变及愈合情况。结果观察组总有效率90.67%;对照组总有效率77.78%,临床治疗效果明显优于对照组（P〈0.05）。两组治疗后中医证候积分均明显改善,而观察组积分经治疗后明显低于对照组（P〈0.05）。两组患者治疗前后疾病活动指数,Baron评分,Geboes指数均下降（P〈0.05）,治疗后观察组评分显著低于对照组（P〈0.05）。两组经治疗后Ig G、Ig M水平及TNF-α、IL-6、IL-8水平均明显下降,观察组显著低于对照组（P〈0.05）,Ig A水平无明显变化（P〉0.05）。结论：针刺联合肠炎清治疗大肠湿热证活动期溃疡性结肠炎具有良好的临床疗效,能显著改善患者临床症状及血清免疫球蛋白和炎症因子水平,促进患者肠黏膜恢复。Objective： To analyze the clinical value of acupuncture combined with Changyanqing Decoction in the treatment of ulcerative colitis of large intestine damp-heat syndrome. Methods： From May 2014 to July 2016 in our hospital,a total of 147 cases diagnosed as active ulcerative colitis of large intestine damp-heat syndrome,were randomly divided into two groups according to a random number table grouping method. The control group was treated with Mesalazin Enteric-coated Tablets and the observation group were given acupuncture combined with Changyanqing Decoction. The clinical efficacies of the two groups were observed,and the scores of TCM syndromes were compared between the two groups before and after treatment. The levels of serum immunoglobulin（ Ig A,Ig G,Ig M）,tumor necrosis factor alpha（ TNF-α）,interleukin-6（ IL-6） and interleukin-8（ IL-8）were detected before and after treatment. The pathological changes and healing of colonic mucosa were evaluated by the mucosal lesion activity index,Baron score and Geboes index. Results： The total effective rate of the observation group was 90. 67% and that of the control group was 77. 78%,and the clinical effect was significantly better than that of the control group（ P 〈 0. 05）. After treatment,TCM syndrome scores of the two groups were significantly improved,while the observation group’ s after treatment was significantly lower than that of the control group（ P 〈 0. 05）. In the two groups before and after treatment,disease activity indexes,Baron scores and Geboes indexes were decreased（ P 〈 0. 05）. The observation group’s was significantly lower than that of the control group（ P 〈 0. 05）. After treatment,the levels of Ig G,Ig M and TNF-α,IL-6 and IL-8 were significantly decreased in the two groups and the observation group’s were significantly lower than those in the control group（ P 〈 0. 05）,and the level of Ig A was not significantly changed（ P 〉 0. 05）. Conclusion： Acupuncture combined with Changyanqing

关 键 词：针灸 肠炎清 大肠湿热证 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]