2016年中山市6～13岁学龄儿童鼻咽部肺炎链球菌携带情况及药物敏感性分析  

Prevalence and drug susceptibility of Streptococcus pneumoniae isolated in the nasopharynx of school children aged 6-13 years in Zhongshan City,2016

作　　者：陈燕辉[1] 陈晓媚[1] 杨晓华[1] 袁春雷[1] 谭南[1] CHEN Yan-hui;CHEN Xiao-mei;YANG Xiao-hua;YUAN Chun-lei;TAN Nan(Boai Hospital of Zhongshan City, Zhongshan, Guangdong 528403, Chin)

机构地区：[1]中山市博爱医院,广东中山528403

出　　处：《实用预防医学》2018年第5期554-556,共3页Practical Preventive Medicine

基　　金：中山市科技计划项目(2015B1181)

摘　　要：目的了解中山市6~13岁学龄儿童鼻咽部肺炎链球菌携带情况及药物敏感性情况。方法 2016年10-12月期间对中山市3所小学的学生进行调查,按各校的学生总人数和各年级的学生人数情况进行抽样,共选取253名学龄儿童,采集咽拭子,检测肺炎链球菌并开展药敏试验。结果年龄为6~、9~、12~13岁儿童肺炎链球菌阳性携带率分别为12.8%(10/78)、15.89%(17/107)、7.35%(5/68),各年龄段相比差异有统计学意义(χ~2=9.441,P=0.043),各年龄段不同性别的肺炎链球菌携带率比较差异无统计学意义(P>0.05)。50株肺炎链球菌对阿莫西林和左氧氟沙星的敏感性高达100%,对头孢曲松和氯霉素也有较高的敏感性;而对红霉素和阿奇霉素的耐药性高达96.00%,对四环素耐药性高达78.00%。结论 2016年中山市6~13岁学龄儿童鼻咽部肺炎链球菌携带普遍,且对阿莫西林、左氧氟沙星、青霉素、头孢曲松和氯霉素敏感性较高。Objective To investigate the carrying status and drug susceptibility of Streptococcus pneumoniae isolated in the nasopharynx of school children aged 6-13 years in Zhongshan City in 2016. Methods According to the total number of students in each school and the number of students in each grade, a total of 253 school-age children were selected from 3 primary schools in Zhongshan City from October to December in 2016. Oropharyngeal swabs were collected to detect Streptococcus pneumoniae, and then antimicrobial susceptibility testing was performed. Results The positive carrying rates of Streptococcus pneumoniae in children aged 6-, 9- and 12-13 years were 12.8% （10/78）, 15.89%（17/107） and 7.35% （5/68） respectively, showing statistically significant differences among different age groups （χ2=9.441, P=0.043）. But no statistically significant difference was found in the carrying rate of Streptococcus pneumoniae between males and females with different ages （P〉0.05）. 50 strains of Streptococcus pneumoniae were highly sensitive to amoxicillin （100%）, levofloxacin （100%）, ceftriaxone （82%） and chloramphenicol （86%）, but highly resistant to erythromycin （96%） and azithromycin （96%） and tetracycline （78%）. Conclusions Streptococcus pneumonia infection in the nasopharynx of school children aged 6-13 years in Zhongshan City in 2016 was prevalent; moreover, it is highly sensitive to amoxicillin, levofloxacin, penicillin, ceftriaxone and chloramphenicol.

关 键 词：学龄儿童 肺炎链球菌 携带率 药物敏感性 

分 类 号：R378[医药卫生—病原生物学]