补阳还五汤对气虚血瘀型肺癌患者血液高凝状态的影响  

Buyang Huanwu Tang Has Effect on Blood Hypercoagulable State in Patients with Lung Cancer of Qi Deficiency and Blood Stasis Type

作　　者：郑青秀[1] 徐小小 刘刚[1] 马晓东[1] ZHENG Qingxiu;XU Xiaoxiao;LIU Gang;MA Xiaodong

机构地区：[1]温州市中医院呼吸内科,浙江温州325000

出　　处：《新中医》2018年第3期146-148,共3页New Chinese Medicine

基　　金：温州市2016年公益性科技计划项目(Y20160094)

摘　　要：目的:观察补阳还五汤对气虚血瘀型肺癌患者血液高凝状态的影响。方法:将60例气虚血瘀型肺癌患者随机分为2组各30例,对照组采用常规营养支持治疗,治疗组在对照组治疗方案的基础上加用补阳还五汤治疗。比较2组治疗前后相关高凝状态指标[D-二聚体、纤维蛋白原(FIB)、血小板计数(BPC)、组织型纤溶酶原激活物(t PA)、纤溶酶原激活物抑制物-1(PAI-1]的变化情况。结果:治疗组治疗第7、14、28天FIB、D-二聚体、BPC、tPA、PAI-1分别与治疗前比较,差异均有统计学意义(P<0.05)。治疗第28天,2组FIB、D-二聚体、BPC、tPA、PAI-1组间比较,差异均有统计学意义(P<0.05)。结论:补阳还五汤可以改善气虚血瘀型肺癌患者血液高凝状态。Objective：To observe the effect of Buyang Huanwu tang on hypercoagulable state in patients with lung cancer of qi deficiency and blood stasis type. Methods：Divided 60 cases of patients with lung cancer of qi deficiency and blood stasis type randomly,30 cases in each group. The control group received conventional nutritional support treatment,while the treatment group was additionally given Buyang Huanwu tang based on the treatment of the control group. Compared changes of related indexes of hypercoagulable state in two groups before and after treatment,including D-dimer,fibrinogen（FIB）, blood platelet count（BPC）, tissue-type plasminogen activator（tPA） and plasminogen activator inhibitor-1（PAI-1）.Results：The comparisons of FIB,D-dimer,BPC,tPA and PAI-1 in the treatment group on the 7-（th）、14-（th）、28-（th） day of treatment and before treatment showed significance in differences（P〈0.05）. Besides,the respective comparisons of the above indexes between the two groups showed significance in differences（P〈0.05）. Conclusion：Buyang Huanwu tang can improve the hypercoagulable state in patients with lung cancer of qi deficiency and blood stasis type.

关 键 词：肺癌 气虚血瘀型 补阳还五汤 高凝状态 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 D-二聚体 纤维蛋白原 

分 类 号：R734.2[医药卫生—肿瘤]