抗氧化应激指标与中老年人认知减退关系的研究  

Association of cognitive decline with antioxidant index in middle-aged and elderly people

作　　者：秦小霞[1] 邵云[2] 武艳[1] 闫国超[1] QIN Xiao- xia;SHAO Yun;WU Yan;YAN Guo- chao(Clinical Laboratory, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China)

机构地区：[1]河北医科大学第一医院检验科,河北石家庄050031 [2]河北医科大学第一医院超声科,河北石家庄050031

出　　处：《中国卫生检验杂志》2018年第7期819-820,共2页Chinese Journal of Health Laboratory Technology

基　　金：国家863计划子课题(2014AA022304)

摘　　要：目的探讨中老年人认知功能减退与抗氧化指标的关系。方法收集40例认知功能减退患者作为认知减退组,同时选取30例认知功能正常者作为对照组,抽取空腹静脉血,用自动生化分析仪测定两组血清超氧化物歧化酶(SOD)、总蛋白(TP)、白蛋白(ALB)等指标。结果认知减退组SOD、TP、ALB水平均低于对照组,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄、SOD、TP、ALB水平与预测认知功能减退有关(P<0.05)。结论认知功能减退患者血清SOD、TP、ALB水平下降,提高SOD、TP、ALB水平可能对认知功能具有保护作用。Objective To study the correlation between antioxidant index and cognitive decline in the middle-aged and elderly people.Methods A total of 40 patients with cognitive decline were selected as the cognitive decline group（RD）,and 30 subjects with normal cognition were selected as the control group.The serum superoxide dismutase（SOD）,total protein（TP）,albumin（ALB）and other indicators were determined by the automatic biochemical analyzer.Results The levels of SOD,TP and ALB in the cognitive decline group were significantly lower than the control group,with the differences statistically significant（P 0.05）.Logistic regression results showed that age,SOD,TP,ALB levels had correlation with cognitive decline（P 0.05）.Conclusion The serum levels of SOD,TP and ALB in the patients with cognitive decline decreased,and raising the levels of SOD,TP and ALB could have protective effects on cognitive function.

关 键 词：氧化应激 超氧化物歧化酶 白蛋白 认知减退 

分 类 号：R749.1[医药卫生—神经病学与精神病学]