免疫检测点在宫颈癌中的研究进展  

Advances in Immune Checkpoint Therapy in Cervical Cancer

作　　者：杨潇[1] 王艳清[1] 鲜舒 程艳香[1] YANG Xiao;WANG Yan-qing;XIAN Shu;et al.(Renmin Hospital of Wuhan University, W uhan 430060, Chin)

机构地区：[1]武汉大学人民医院

出　　处：《肿瘤学杂志》2018年第3期258-263,共6页Journal of Chinese Oncology

基　　金：湖北省科技厅科技项目支撑计划(2015BCA313);湖北省卫计委一般面上项目(WJ2015MB084);国家自然科学基金(81302273)

摘　　要：T细胞是杀伤表达肿瘤特异性抗原的肿瘤细胞的重要成分。众所周知,肿瘤免疫逃逸是肿瘤发生发展的一个重要机制。免疫检测点治疗是以T细胞的调节通路为靶点来提高抗肿瘤效应的治疗方法。近年来,免疫检测点参与肿瘤免疫逃逸而受到极大的关注,并在肿瘤免疫治疗方面取得了有效进展。全文就免疫检测点与宫颈癌治疗的应用研究进展作一综述。T cells are important components of killing tumor cells that express tumor specific antigen.It is well known that tumor immune escape is an important mechanism of tumor development.Immune checkpoint therapy is a therapeutic approach to improve the anti-tumor effect by targeting regulatory pathway of T cells.In recent years,the immune checkpoint is involved in tumor immune escape,and it has made great progress in tumor immunotherapy.In this paper,we reviewed the progress in the application of Immune checkpoint and cervical cancer treatment.

关 键 词：免疫检测点 PD-1 CTLA-4 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]