重复经颅磁刺激治疗精神分裂症的疗效及对患者认知功能的影响  

The effect of repetitive transcranial magnetic stimulation on schizophrenia and its effect on cognitive function

作　　者：符传创 范长河[2] 甘晓文 黎柱培 袁丁 FU Chuanchuang;FAN Changhe;GAN Xiaowen(Department of psychiatr;the Seventh People＇s Hospital of Dongguan, Dongguan 523220, China)

机构地区：[1]广东省东莞市第七人民医院精神科,东莞523220 [2]广东省人民医院(广东省精神卫生研究所)心理精神科 [3]广东省东莞市第七人民医院睡眠心理科

出　　处：《国际精神病学杂志》2018年第2期253-255,共3页Journal Of International Psychiatry

摘　　要：目的探究重复经颅磁刺激治疗精神分裂症的临床疗效,为临床治疗方案拟定提供依据。方法研究对象选取为2015年1月~2016年12月之间我院收治的126例精神分裂症患者,采用数字表法随机分为A、B、C组,每组各42例,A组患者仅采用利培酮治疗,B组和C组在利培酮治疗基础上进行重复经颅磁刺激治疗,B组患者给予10Hz的伪刺激治疗,C组患者给予10 Hz的真刺激治疗,采用阳性和阴性症状量表评分表(PANSS)评价对比各组疗效情况,同时对比治疗前后各组事件相关电位P300情况。结果总有效率C组显著高于A组、B组(P<0.05),但A组与B组之间对比并无显著差异(P<0.05);治疗后A组、B组的P300指标与治疗前对比无显著差异(P>0.05),C组Fz、Cz点的P3、NP3潜伏期较治疗前明显缩短,波幅明显增高(P<0.05)。结论在利培酮治疗基础上应用10Hz的重复经颅磁刺激可有效改善精神分裂症患者的认知功能,并提高疗效。Objective To explore the clinical effect of repetitive transcranial magnetic stimulation in the treatment of schizophrenia. Methods A total of 126 patients with schizophrenia were enrolled and randomly divided into A, B and C 3 groups （n=42） . The patients in group A were treated with risperidone alone, Group B and group C were treated with repetitive transcranial magnetic stimulation on the basis of risperidone therapy. Group B patients were given lOHz pseudo-stimulating therapy. Group C patients were given 10 Hz true stimulation therapy. PANSS was used to eval- uate the efficacy of each group. Comparison of the event-related potential P300 before and after treatment. Results The total effective rate of C group was significantly higher than that of group A and group B （P〈 0.05 ）, but there was no significant difference between group A and group B （P〈O.05） . The latency of P3 and NP3 in Fz and Cz of group C was significantly shorter than that before treatment （ P 〈 0.05 ） . There was no significant difference between the two groups （ P〉 0.05 ） . Conclusion lOHz repetitive transcranial magnetic stimulation can improve the cognitive function of schizophrenia patients and improve the curative effect on the basis of risperidone therapy.

关 键 词：精神分裂症 认知功能 重复经颅磁刺激 

分 类 号：R749.3[医药卫生—神经病学与精神病学]