卒中后抑郁的脑磁共振低频振幅变化及其与临床症状的关系  

Changes of cerebral resting amplitude of low frequency fluctuation in patients with post-stroke depression and its relationship with clinical symptoms

作　　者：曾义 王曦 黄忠[1] 赵戈[1] 马中锐[1] ZENG Yi;WANG Xi;HUANG Zhong(The Fifth People＇ s Hospital ofChengdu, Chengdu 611130, China)

机构地区：[1]成都市第五人民医院神经内科,成都611130 [2]成都市第五人民医院内分泌科

出　　处：《国际精神病学杂志》2018年第2期305-307,共3页Journal Of International Psychiatry

摘　　要：目的探讨卒中后抑郁(PSD)的脑磁共振低频振幅(ALFF)变化及其与临床症状的关系。方法纳入32例PSD患者及35例年龄、性别、卒中病程相匹配的无PSD脑卒中患者,采用3.0T核磁进行脑部扫描,采用ALFF方法分析两组患者大脑区域活性的变化,并采用Pearson相关性分析差异脑区与蒙哥马利抑郁量表(MADRS)评分的相关性。结果相比对照组,PSD患者存在右侧中央前回(Z=-2.737,P<0.01)、左侧额下回(Z=-2.775,P<0.01)和左侧缘上回(Z=-2.338,P<0.01)的ALFF值降低,且右侧中央前回的ALFF值与MADRS评分呈显著负相关(r=-0.428,P=0.015)。结论 PSD患者大脑存在多个脑区的活性降低,且与临床症状相关,对临床PSD的客观性评估具有重要参考意义。Objective To investigate the changes of cerebral resting amplitude of low frequency fluctuation （ALFF） in patients with post-stroke depression （ PSD ） and its relationship with clinical symptoms. Method 32 patients with PSD and 35 non-PSD stroke patients were enrolled in this study. The ALFF method was used to analyze the changes of brain regions in patients with PSD during in the resting-state functional MRI. Pearson correlation was used to analyze the correlation between different brain regions and the Montgomery Depression Rating Scale （ MADRS ） . Results Compared with the control group, the patients with PSD had decreased ALFF in right precentral gyrus （ Z=-2.737, P〈0.01 ）, left inferior frontal gyrus （ Z=-2.775, P〈0.01 ） and left supramarginal gyrus （ Z=-2.338, P〈 0.01 ） . The ALFF of the right precentral frontal gyrus was negatively correlated with the MADRS score （r=-0.428, P = 0.015 ） . Conclusion The activity of multiple brain regions in PSD patients is decreased and correlated with clinical symptoms, which provides an important reference for the objective evaluation of clinical PSD.

关 键 词：卒中后抑郁 低频振幅 症状 相关性 

分 类 号：R749.13[医药卫生—神经病学与精神病学]