子宫内膜细胞蜡块切片在子宫内膜癌早期诊断的应用  

Application of endometrial cell wax block examination in early diagnosis of endometrial cancer

作　　者：陈雪[1] 周炳娟[1] 孙吉瑞 张丙信[1] 乔海芝 张金库[1] CHEN Xue;ZHOU Bingjuan;SUN Jirui;ZHANG Bingxin;Q.IAO Haizhi;ZHANG Jinku(Department of Pathology, First Central Hospital of Baoding, Baoding Hebei 071000j China)

机构地区：[1]保定市第一中心医院病理科,河北保定071000

出　　处：《临床与病理杂志》2018年第3期485-489,共5页Journal of Clinical and Pathological Research

摘　　要：目的:探讨应用子宫内膜细胞蜡块切片检查法对子宫内膜癌及其他病变早期诊断的临床应用价值。方法:收集自2016年6月至12月因不规则阴道出血、绝经后出血、子宫内膜增厚等原因于保定市第一中心医院妇科门诊就诊的患者共80例。用子宫内膜刷刷取患者内膜细胞,95%乙醇溶液固定、石蜡包埋、切片后行HE染色;同时对患者行诊刮,以组织病理切片作为诊断标准,分析两种方法在子宫内膜病变诊断中的符合率。结果:内膜细胞蜡块切片法在诊断子宫内膜癌的敏感性为83.33%,特异性为98.21%,阳性预测值为95.23%,阴性预测值为93.22%,诊断效率为93.75%。在诊断子宫内膜良性病变方面,敏感性为79.31%,特异性为96.08%,阳性预测值为92.00%,阴性预测值为89.09%,诊断效率为90.00%。结论:子宫内膜细胞蜡块切片检查法是一种简便易行、可靠的子宫内膜病变早期诊断方法。Objective： To study the clinical application of endometrial cell block examination in early diagnosis of endometrial cancer and other diseases. Methods： From June to December of 2016, specimens of 80 patients from gynecological clinic at risk for developing endometrial cancer were examined. Endometrial cells were brushed, fixed by 95% alcohol, embedded by paraffin, sliced up and HE stained. The diagnosis of specimens obtained through curettage was regarded as diagnostic standard, and analyzed the diagnostic accordance rate of endometrial cell block screening for endometrial cancer and benign endometrial lesions. Results： Endometrial cell block examination demonstrated a sensitivity of 83.33% for endometrial cancer and 79.31% for benign endometrial lesions. The specificity of endometrial cell block examination were 98.21% for endometrial cancer and 96.08% for benign endometrial lesions. The positive predictive value, negative predictive value and diagnostic efficiency were 95.23%, 93.22% and 93.75% for endometrial cancer. The positive predictive value, negative predictive value and diagnostic efficiency were 92.00%, 89.09% and 90.00% for benign endometrial lesions. Conclusion： Endometrial cell block examination is a simple, safe and reliable method for early diagnosis of endometrial lesions.

关 键 词：细胞蜡块 子宫内膜癌 HE染色 

分 类 号：R737.33[医药卫生—肿瘤]