康莱特注射液联合GP方案治疗中晚期非小细胞肺癌随机平行对照研究  

Non-small Cell Lung Cancer Randomized Parallel Controlled Study of Advanced Kanglaite Injection combined with GP in Treatment

作　　者：陈成 CHEN Cheng(Department of Oncology in Gucheng People＇s Hospital,Gucheng 441700,Hubei,China)

机构地区：[1]谷城县人民医院肿瘤科,湖北谷城441700

出　　处：《实用中医内科杂志》2018年第3期46-48,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察康莱特注射液联合GP方案治疗中晚期非小细胞肺癌疗效。[方法]使用随机平行对照方法,将60例住院患者按病志号抽签方法随机分为两组。对照组30例GP方案:吉西他滨,1000mg/m^2,第1d、第8d,静滴;顺铂,25mg/m^2,d1~d3,静注。治疗组30例康莱特,200mL/d,缓慢静滴;GP方案治疗同对照组。连续治疗3周为1疗程。观测临床症状、骨髓抑制、消化道反应、肝功能受损、不良反应。治疗1疗程(3周),判定疗效。[结果]RR、DCR两组无显著差异(P>0.05);骨髓抑制、肝功能受损治疗组少于对照组(P<0.05),消化道反应两组无显著差异(P>0.05)。[结论]康莱特联合GP方案治疗非小细胞肺癌,能降低单纯GP方案的毒副反应,值得推广。[Objective] To observe the curative effect of advanced Kanglaite Injection combined with GP chemotherapy in treatment of non-small cell lung cancer. [Methods] 60 cases of hospitalized patients were randomly divided into two groups by random parallel control method. In the control group, 30 cases of GP program： Gemcitabine, 1000 mg/m^2, 1 d, 8 d, intravenous drip, cisplatin, 25 mg/m^2, d1 to d3, intravenous infusion. The treatment group of 30 cases of Kanglaite, 200 mL/d, slow intravenous infusi P regimen treatment with the control group. Continuous treatment for 3 weeks was the 1 course of treatment. Clinical symptoms, myelosuppression, digestive tract reactions, impaired liver function, and adverse reactions were observed. The 1 course of treatment（3 weeks） was treated and the curative effect was determined. [Results] there was no significant difference in RR and DCR between the two groups（P〈0.05）. Bone marrow suppression, digestive tract reaction and liver function damage in the treatment group were less than those in the control group（P〈0.05）, and there was no significant difference in the gastrointestinal reaction between the two groups（P〈0.05）. [Conclusion] Kanglaite combined with GP regimen in the treatment of non-small cell lung cancer can reduce the toxicity of GP regimen alone, is worthy of promotion.

关 键 词：非小细胞肺癌 康莱特 GP方案 吉西他滨 顺铂 骨髓抑制 消化道反应 肝功能 不良反应 随机平行对照研究 

分 类 号：R734.2[医药卫生—肿瘤]