肿瘤免疫治疗与PD-1／PD-L1抑制剂的研究进展  

Research progress of tumor immunotherapy and PD-1/PD-L1 inhibitors

作　　者：董银萍 李德冠[1,2] Dong Yinping;Li Deguan(Institute of Radiation Medicine, Chinese Academy of Medical Science ＆ Peking Union Medical Colleg;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin 300192, China)

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所,天津300192 [2]天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《国际生物医学工程杂志》2018年第1期72-77,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金（81573094,81102873）;天津市自然科学重点基金（15JCzDJC35200）;中国医学科学院医学与健康科技创新工程项目（2017-12M-019）

摘　　要：免疫疗法已成为继手术治疗、放射治疗和化学药物治疗之后的一种新的治疗恶性肿瘤的手段。肿瘤的免疫治疗是基础研究和临床的研究热点，检查点蛋白抑制剂的研究更受关注。研究结果证实，阻断一些检查点，如细胞毒性T淋巴细胞相关抗原-4（CTLA-4）和程序性死亡蛋白-1（PD-1），对实体肿瘤的治疗可发挥免疫调控作用。免疫检查点抑制剂是近年来发挥良好疗效的药物。PD-1/程序性死亡配体-1（PD-L1）信号通路是肿瘤免疫逃逸的重要途径之一。以PD-1/PD-L1为靶点的药物可重新激活抗肿瘤免疫并在多种肿瘤的治疗中取得了良好疗效。但抗PD-1/PD-L1治疗也有不良反应发生，且治疗的反应率有待提高。主要针对PD-1/PD-L1信号通路以及PD-1/PD-L1抗体药物在恶性黑色素瘤、肺癌、肾细胞癌、胃肠道癌及膀胱癌等实体瘤中的免疫治疗研究进展作一综述。Immunotherapy has become a new treatment for malignant tumors following surgery,radiotherapy,and chemotherapy.Tumor immunotherapy is a hot topic in basic medical research and clinical research,in which the study on checkpoint protein inhibitors has attracted more attention.The previous studies confirmed that blocking certain checkpoints,such as cytotoxic T lymphocyte-associated antigen-4（CTLA-4）and programmed cell death protein-1（PD-1）,can exert immunomodulatory effects in solid tumor treatments.Immune checkpoint inhibitors have demonstrated good efficacy in recent years.The PD-1/programmed death ligand-1（PD-L1）signaling pathway is one of the important pathways for tumor immune escape.PD-1/PD-L1-targeted drugs can reactivate anti-tumor immunity and achieve good therapeutic effects in the treatment of various tumors.However,anti-PD-1/PD-L1 treatment has a certain adverse reaction rate,and the response rate of treatment needs to be improved.In this paper,the research progress of PD-1/PD-L1 signaling pathway and anti-PD-1/PD-L1 drugs in the treatment of solid tumors was summarized,such as malignant melanoma,lung cancer,renal cell carcinoma,gastrointestinal cancer,bladder cancer,etc.

关 键 词：免疫治疗 免疫检查点 程序性死亡蛋白-1 程序性死亡配体-1 肿瘤 

分 类 号：R730.51[医药卫生—肿瘤]