大动脉粥样硬化型缺血性卒中易感基因研究进展  

Research progress of susceptibility genes associated with large artery atherosclerotic ischemic stroke

作　　者：刘兰[1] 王为珍[2] 王乔树[1] LIU Lan;WANG Wei-zhen;WANG Qiao-shu(Department of Neurology;International Medical Care Center, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China)

机构地区：[1]上海交通大学附属第一人民医院神经内科,200080 [2]上海交通大学附属第一人民医院国际医疗保健中心,200080

出　　处：《中国现代神经疾病杂志》2018年第4期278-283,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:81371304)~~

摘　　要：脑卒中是严重威胁人类健康的疾病之一,具有高发病率、高病残率和高病死率等特点。遗传因素在脑卒中发病中发挥重要作用,动脉粥样硬化、高血压、糖尿病、高脂血症和心脏病等是脑卒中的危险因素,均与遗传因素相关。脑卒中易感基因是目前国内外研究的热点之一,本文拟就大动脉粥样硬化型缺血性卒中易感基因研究进展进行综述。Stroke is one of the serious threats to human health, with high incidence, morbidity andmortality. Studies have shown that genes play an important role in the pathogenesis of stroke.Atherosclerosis, hypertension, diabetes, hyperlipidemia and heart disease are risk factors for stroke, and areassociated with inheritance. Stroke susceptibility gene is one of the hotspots at home and abroad. Thisarticle reviews the progress of susceptibility genes in large artery atherosclerotic ischemic stroke.

关 键 词：卒中 脑缺血 动脉粥样硬化 基因 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]