醒脑静注射液、尤瑞克林联合治疗对脑梗死病人神经功能缺损及脑血流动力学的影响  

Effects of Xingnaojing Injection and Urinary Kallidinogenase on Neurological Impairment and Cerebral Hemodynamics in Patients with Cerebral Infarction

作　　者：李丹[1] 韩冰 Li Dan;Han Bing(Bayannur Hospital, Bayannur 015000, Inner Mongolia, China)

机构地区：[1]内蒙古巴彦淖尔市医院,内蒙古巴彦淖尔015000 [2]内蒙古自治区人民医院

出　　处：《中西医结合心脑血管病杂志》2018年第7期846-848,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的分析醒脑静注射液、尤瑞克林联合治疗对脑梗死病人神经功能缺损及脑血流动力学的影响。方法选取内蒙古巴彦淖尔市医院收治的114例脑梗死病人作为研究对象,采用分层随机法分为对照组(醒脑静注射液治疗)和观察组(醒脑静注射液+尤瑞克林治疗)。观察两组病人治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(Barthel)评分、脑部血流动力学指标变化,比较两组临床疗效。结果治疗前两组病人NIHSS评分均较高,差异无统计学意义(P>0.05);治疗后7d、14d、21d,观察组NIHSS评分较对照组显著下降(P<0.05);治疗后21d、60d,观察组Barthel评分显著高于对照组(P<0.05);治疗前两组病人脑部血流动力学指标比较差异无统计学意义(P>0.05),但治疗后7d、14d、21d,观察组脑部血流动力学指标显著优于对照组,差异有统计学意义(P<0.05);经过1个疗程的治疗,对照组治疗总有效率为80.7%,观察组治疗总有效率为91.2%,两组比较差异有统计学意义(P<0.05)。结论醒脑静注射液、尤瑞克林联合治疗脑梗死能显著提高临床疗效,有效改善脑部血流动力学,减少对神经功能的损害,提高日常活动能力。Objective To investigate the effects of Xingnaojing injection （ XNJI）and urinary kallidinogenase on neurological impairmentand cerebral hemodynamics in patients with cerebral infarction.Methods One hundred and fourteen patients with cerebral infarctionfrom Bayannur Hospital were randomly divided into two groups： control group （ n =57）treated with XNJI, and treatment group （ n =57）treated with XNJI and urinary kallidinogenase.The scores of National Institutes of Health Stroke Scale （ NIHSS） , activity of dailyliving （ Barthel） , and cerebral hemodynamic parameters were observed before and after treatment.The clinical efficacy of the twogroups were compared.Results NIHSS score were higher in two groups before treatment, and there was no significant differencebetween two groups （ P 〉0.05） .NIHSS scores in treatment group showed a significant decrease compared with control group after 7days, 14 days, 21days of treatment （ P 〈0.05） .Barthel scores were higher in treatment group than that in control group after 21 days,60 days of treatment （ P 〈0.05） .After 1 courses of treatment, the total clinical effective rate was significantly higher in treatmentgroup than that in control group （ 91.2% vs 80.7%, P 〈0.05） .Conclusion XNJI and urinary kallidinogenase can significantly improvethe treatment efficiency, improve brain hemodynamics, reduce neurological damage and improve the ability of daily activities in pa -tients with cerebral infarction.

关 键 词：脑梗死 醒脑静注射液 尤瑞克林 神经功能缺损 血流动力学 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R289.5[医药卫生—临床医学]