地佐辛在肝癌射频消融中的镇痛效果研究  

Analgesic effect of dezocine in radio frequency ablation for treatment of hepatic carcinoma

作　　者：王运良[1] 李智[2] 闫乐乐 李明明[2] 沈健[2] 邹建伟[2] Wang Yunliang;Li Zhi;Yan Lele;Li Mingming;Shen Jian;Zou Jianwei(Department of General Surgery;Department of lnterventional Radiology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院普外科,215006 [2]苏州大学附属第一医院介入科,215006

出　　处：《中华介入放射学电子杂志》2018年第2期109-112,共4页Chinese Journal of Interventional Radiology：electronic edition

基　　金：苏州科技局民生科技项目(SYS201611&KJXW2016005)

摘　　要：目的:研究地佐辛在肝癌射频消融(RFA)术中的镇痛效果。方法:选取2014年1月—2016年10月我科收治的60例行RFA治疗的肝癌患者,随机分为两组。A组术前肌注哌替啶75 mg。B组术前肌注地佐辛0.1 mg/kg,术中静脉泵入地佐辛0.5 mg/kg·h。比较两组的RFA完成情况、术中术后视觉模拟评分(VAS)、患者满意度评分及不良反应发生率。结果:A组28例、B组30例不间断完成RFA手术。术中B组的VAS评分显著低于A组(3.3±1.7 vs.5.9±1.4,P<0.05),术后B组的VAS评分显著低于A组(2.3±1.4 vs.4.6±1.3,P<0.05)。B组满意度评分(1分:非常好、2分:好、3分:一般、4分:不好)分别为8、13、7、1例,A组分别为3、10、12、5例,B组患者术后的满意度评分较好者的比例高于A组,差异有统计学意义(P<0.05)。B组不良反应发生率显著低于A组(6.7%vs.16.7%,P<0.05)。结论:采用地佐辛镇痛可以保障肝癌RFA手术的完成,其效果优于哌替啶。Objective：To investigate the analgestic effect of dezocine in radio frequency ablation （RFA） for the treatment of hepatic carcinoma. Methods： Sixty patients with hepatic carcinoma were enrolled in this study.These patients were randomly divided into two groups： Group A （n=28） and Group B （n=30）.Before operation,the patients in Group A were IM given pethidine （75 mg） while the patients in Group B were treated with dezocine （0.1 mg/kg）.The visual analogue scale （VAS） and patients satisfaction scale were used to evaluate the comfort degree,and the incidence rates of adverse drug reactions were also recorded. Results：In the operation,the VAS score in Group B was lower than that of the Group A （3.3±1.7 vs. 5.9±1.4） and the difference was statistically significant （P〈0.05）. After operation,the VAS score in Group B was lower than that of Group A （2.3±1.4 vs. 4.6±1.3） and the difference was statistically significant （P〈 0.05 ）. Satisfaction level （1：very good,2：good,3：general,4：bad ） in group B （8,13,7,1） was better than that in group A （3,10,12,5） and the difference was statistically significant （P〈0.05）.Conclusions：The use of dezocine can ensure the completion of RFA operation for HCC, and the effect is better than that of pethidine.

关 键 词：地佐辛 哌替啶 镇痛 肝恶性肿瘤 射频消融 

分 类 号：R735.7[医药卫生—肿瘤]