血清chemerin水平与非酒精性脂肪性肝病的相关性  

Correlation between serum chemerin level and non-alcoholic fatty liver disease

作　　者：吕骥 闫丽丽[1] 贾红玉 吕喆[1] 徐梅梅[1] LV Ji;YAN Li-li;JIA Hong-yu;LV Zhe;XU Mei-mei(Department of Medicine, the First Hospital ofQinhuangdao, Qinhuangdao 066000, Hebei Province, Chin)

机构地区：[1]秦皇岛市第一医院内科,河北秦皇岛066000

出　　处：《中国肝脏病杂志（电子版）》2018年第1期54-58,共5页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的研究血清chemerin水平与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的相关性。方法选取2015年6月至2016年8月秦皇岛市第一医院收治的NAFLD患者56例为研究对象,并从该院体检中心随机抽取同期糖耐量试验正常者60例为对照组。检测并比较两组受试者血清chemerin水平、糖化血红蛋白(hemoglobin A1C,Hb A1C)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、体重指数(body mass index,BMI)及腰臀比(waist-to-hip ratio,WHR)等指标。采用Pearson相关分析空腹血清chemerin水平与上述各指标的相关性并采用多元线性回归分析血清chemerin的影响因素。结果 NAFLD患者血清chemerin水平[(79.71±10.36)nmol/ml]显著高于健康对照者[(62.43±11.92)nmol/ml;t=8.308,P<0.001]。空腹血清chemerin水平与BMI、WHR、Hb A1C、HOMA-IR和TG呈正相关(r=0.382、0.492、0.442、0.590、0.295,P均<0.05),与HDL-C呈负相关(r=-0.314,P=0.003)。以chemerin为因变量进行多元线性回归分析显示,Hb A1C、Lg HOMA-IR和WHR为空腹血清chemerin水平的影响因素(P<0.001)。结论 NAFLD患者血清chemerin水平增高,糖化血红蛋白、胰岛素抵抗指数和腰臀比是影响chemerin的关键指标,提示chemerin与NAFLD的发生发展密切相关。Objective To investigate the correlation between serum chemerin level and non-alcoholic fatty liverdisease （NAFLD）. Methods A total of 56 patients with NAFLD and 60 health controls with normal glucosetolerance in the First Hospital of Qinhuangdao from June 2015 to August 2016 were selected. The levels ofserum chemerin, hemoglobin A1C （HbA1C）, homeostasis model assessment-insulin resistance index （HOMAIR）,triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, body mass index （BMI） and waist-to-hipratio （WHR） were tested and compared. Pearson anlysis was used to analyze the correlation between serumchemerin and the above indexes and multiple linear regression was employed to explore the influence factorsof serum chemerin level. Results The serum chemerin levels of patients in NAFLD group were significantlyhigher than those of the control group [（79.71 ± 10.36） nmol/ml vs （62.43 ± 11.92） nmol/ml; t = 8.308, P 〈0.001]. The levels of serum chemerin were positively correlated with BMI, WHR, HbA1C, LgHOMA-IR andTG （r = 0.382, 0.517, 0.442, 0.590, 0.295; P 〈 0.05）, and were negatively correlated with HDL-C （r = -0.314,P = 0.003）. Multiple linear regression analysis showed that HbA1C, LnHOMA-IR and WHR were the influencefactors of serum chemerin level （P 〈 0.001）. Conclusions Patients with NAFLD have higher level of serumchemerin, HOMA-IR, HbA1C and WHR are key indicators of serum chemerin, suggesting that chemerin maybe closely associated with non-alcoholic fatty liver disease.

关 键 词：脂肪肝 非酒精性 CHEMERIN 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]