An assessment of antioxidant status in patients with carbon monoxide poisoning  

作　　者：Suat Zengin Behcet A Sahin Karta Basri Can Mustafa Orkmez Abdullah Taskin Ugur Lok Bediha Gulen Cuma Yildirim Seyithan Taysi 

机构地区：[1]Department of Emergency Medicine, Gaziantep University School of Medicine [2]Department of Emergency Medicine, Sehitkamil State Hospital [3]Medical Biochemistry, Gaziantep University School of Medicine [4]Department of Biochemistry, Harran University School of Medicine [5]Department of Emergency Medicine, Adiyaman University [6]Department of Emergency Medicine, Bezmialem Vakif University

出　　处：《World Journal of Emergency Medicine》2014年第2期91-95,共5页世界急诊医学杂志（英文）

摘　　要：BACKGROUND: Carbon monoxide poisoning(COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase(PON), arylesterase(ARYL), ceruloplasmin(Cp), and sulfhydryl(-SH) in the treatment of COP, and to further understand the pathophysiology of COP.METHODS: This prospective study comprised 107 individuals with COP(group 1) and 50 healthy volunteers(group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90 th and 180 th minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and-SH were measured in both groups.RESULTS: Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and-SH levels. PON, ARYL, and-SH levels were signifi cantly decreased in group 1 compared with group 2. Conversely, Cp was signifi cantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90 th and 180 th minutes(P<0.001), Cp was higher on admission than at the other time points(P<0.001).CONCLUSIONS: Participants with COP had decreased levels of antioxidants(PON, ARLY, and-SH). COP represses the antioxidant system.BACKGROUND： Carbon monoxide poisoning （COP） is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase （PON）, arylesterase （ARYL）, ceruloplasmin （Cp）, and sulfhydryl （-SH） in the treatment of COP, and to further understand the pathophysiology of COP. METHODS： This prospective study comprised 107 individuals with COP （group 1） and 50 healthy volunteers （group 2）. Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90th and 180th minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and -SH were measured in both groups. RESULTS： Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and -SH levels. PON, ARYL, and -SH levels were significantly decreased in group 1 compared with group 2. Conversely, Cp was significantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90^th and 180^th minutes （P〈0.001）, Cp was higher on admission than at the other time points （P〈0.001）. CONCLUSIONS： Participants with COP had decreased levels of antioxidants （PON, ARLY, and -SH）. COP represses the antioxidant system.

关 键 词：Carbon monoxide poisoning PARAOXONASE ARYLESTERASE CERULOPLASMIN Tota sulfhydryl groups 

分 类 号：R595.1[医药卫生—内科学]