supported by grants to S.C.from the National Natural Science Foundation of China(82170863);Shanghai Rising-Star Program(21QA1407000),the Lingang Laboratory Grant(LG-QS-202205-06);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20212501);Shanghai Sixth People’s Hospital(ynyq202103);supported by grants to J.L.from the National Key R&D Program of China(2021YFA0804800 and 2018YFA0800600);Shanghai Municipal Commission of Science and Technology(20410713200 and 21S11909000);the National Facility for Translational Medicine(TMSK-2020-102);the‘Shuguang Program’supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(20SG10),and Shanghai Sixth People’s Hospital(ynjq202102).
Nonalcoholic steatohepatitis(NASH)is a condition that progresses from nonalcoholic fatty liver disease(NAFLD)and is characterized by hepatic fat accumulation,inflammation,and fibrosis.It has the potential to develop i...
BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver disease.Some studies have shown that comorbidities may have important effects on WD.Data on hepatitis B virus(HBV)infection in patients with WD a...
supported by the following grants to Junli Liu:National Key R&D Program of China(2018YFA0800600 and 2021YFA0804800).
Human health requires macronutrients,such as amino acids,glucose,and lipids,as well as micronutrients,including copper and iron.Copper is required for the assembly of various enzymes,such as copper/zinc superoxide dis...
Wilson’s disease(WD)is a rare inherited disorder of human copper metabolism,with an estimated prevalence of 1:30000-1:50000 and a broad spectrum of hepatic and neuropsychiatric manifestations.In healthy individuals,t...
Consejería de Salud.Junta de Andalucía,No.PI_0039_2017;Junta de andalucia,No.201799903406796.
Wilson's disease(WD)is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs,such as the central nervous system.It is a hereditary autosomal recessive disease caused by a d...
the Science and Technology Department of Fujian Province,No.2018J01164;Quanzhou Science and Technology Bureau Planning Project,No.2019N019S.
BACKGROUND The presence of significant liver fibrosis in hepatitis B virus(HBV)-infected individuals with persistently normal serum alanine aminotransferase(PNALT)levels is a strong indicator for initiating antiviral ...
Acute coronary syndrome (ACS) is a range of conditions associated with decreased blood flow in the coronary arteries resulting from sudden rupture of atherosclerotic plaques. Several studies have found that oxidative ...
Background and Aims: The liver is the first organ affected by toxic copper in the classical and severe hepatic forms of Wilson's disease(WD).Because their associated chronic liver damage is mostly asymptomatic,an inte...
Purpose: The study aimed at evaluation of the role of ceruloplasmin (A protein involved in iron homeostasis and can inactivate free radicals) and other oxidative stress markers as superoxide dismutase (SOD), malondial...