骨肉瘤中FoxM1、Sox9基因异常表达与肿瘤病理特征的相关性研究  

The correlation of the abnormal expression of FoxM1 and Sox9 in osteosarcoma with the pathologic features of tumor

作　　者：彭贻龙 郑彩云 PENG Yi-long;ZHENG Cai-yun(Department of Bone Surgery,Enshi Youfu Hospital,Enshi 445000, Hubei Province, China;Department of Ultrasonography,Enshi Center Hospital, Enshi 445000, Hubei Province, China)

机构地区：[1]湖北省恩施州优抚医院骨外科 [2]湖北省恩施市中心医院功能科,湖北恩施445000

出　　处：《海南医学院学报》2018年第7期797-799,803,共4页Journal of Hainan Medical University

基　　金：2015湖北省卫计委重点项目(WJ2015MA172)~~

摘　　要：目的:研究骨肉瘤中FoxM1、Sox9基因异常表达与肿瘤病理特征的相关性。方法:选择在恩施州优抚医院接受手术切除的骨肉瘤患者和骨巨细胞瘤患者,经病理检查明确组织性质后纳入研究的骨肉瘤组及对照组。手术后收集病灶组织并测定FoxM1、Sox9基因及增殖基因、侵袭基因的mRNA表达量。结果:骨肉瘤患者病灶组织中FoxM1、Sox9、AURKA、PAK5、IRX2、S100A6、FAK、MMP9、PIPK4、N-cadherin的mRNA表达量显著高于对照组,Id1、TAp73的mRNA表达量显著低于对照组;骨肉瘤组中FoxM1高表达病灶组织中AURKA、PAK5、IRX2的mRNA表达量显著高于FoxM1低表达的病灶组织,Id1、TAp73的mRNA表达量显著低于FoxM1低表达的病灶组织;骨肉瘤组中Sox9高表达病灶组织中S100A6、FAK、MMP9、PIPK4、N-cadherin的mRNA表达量显著高于Sox9低表达的病灶组织。结论:骨肉瘤中FoxM1、Sox9基因的异常高表达分别能够促进肿瘤病灶内细胞的增殖和侵袭。Objective：To study the correlation of the abnormal expression of FoxM1 and Sox9 in osteosarcoma with the pathologic features of tumor.Methods：Patients with osteosarcoma and those with giant cell tumor who received surgical resection in Enshi Youfu hospital between March 2015 and August 2017 were selected and enrolled in the osteosarcoma group and control group of the study after the tissue properties were confirmed by pathological examination.The lesion tissue was collected after operation to determine the mRNA expression of FoxM1,Sox9,proliferation genes and invasion genes.Results：FoxM1,Sox9,AURKA,PAK5,IRX2,S100 A6,FAK,MMP9,PIPK4 and N-cadherin mRNA expression in lesion tissue of osteosarcoma group were significantly higher than those of control group whereas Id1 and TAp73 mRNA expression were significantly lower than those of control group;AURKA,PAK5 and IRX2 mRNA expression in lesion tissue of osteosarcoma group with high FoxM1 expression were significantly higher than those in lesion tissue with low FoxM1 expression whereas Id1 and TAp73 mRNA expression were significantly lower than those in lesion tissue with low FoxM1 expression;S100 A6,FAK,MMP9,PIPK4 and N-cadherin mRNA expression in lesion tissue of osteosarcoma group with high Sox9 expression was significantly higher than those in lesion tissue with low Sox9 expression.Conclusion：The abnormal high expression of FoxM1 and Sox9 in osteosarcoma can promote the cell proliferation and invasion within the tumor.

关 键 词：骨肉瘤 FOXM1 SOX9 增殖 侵袭 

分 类 号：R736.3[医药卫生—肿瘤]