急性脑梗死后非溶栓患者出血转化的危险因素研究  

Study on risk factors of hemorrhagic transformation in patients with acute cerebral infarction after non thrombolysis

作　　者：马丽娜[1] 李兴[2] 余丹[1] 杨国帅[1] 周治平[1] MA Li-na;LI Xing;YU Dan;YANG Guo-shuai;ZHOU Zhi-ping(Department of Neurology, Haikou Hospital Affiliated to Xiangya School of Medicine of Central South University, Hainan, Haikou 570203, China;Department of Cancer Chemotherapy, Haikou Hospital Affiliated to Xiangya School of Medicine of Central South University, Hainan, Haikou 570203, China)

机构地区：[1]中南大学湘雅医学院附属海口医院神经内科,海南海口570203 [2]中南大学湘雅医学院附属海口医院肿瘤化疗科,海南海口570203

出　　处：《海南医学院学报》2018年第6期677-679,共3页Journal of Hainan Medical University

摘　　要：目的:研究急性脑梗死后非溶栓患者出血转化的危险因素。方法:选取在本院神经内科进行住院治疗的急性脑梗死后非溶栓患者96例为研究对象。按照患者是否出现发生出血转化分为出血转化组(48例),未出血转化组(48例)。然后比较两组的脂代谢指标、心房颤动、吸烟史、饮酒史、高血压病史、糖尿病史、血压、发病后开始治疗时间及梗死面积,并采用多因素Logistic回归分析上述因素与本病的关系。结果:两组心房颤动、吸烟史以及饮酒史对比差异明显,差异具有统计学意义(P<0.05);两组入院空腹血糖以及LDL-C水平比较具有显著差异,差异具有统计学意义(P<0.05);两组治疗时间及梗死面积情况对比具有显著差异,差异具有统计学意义(P<0.05);经多因素Logistic回归分析,影响急性脑梗死患者出血转化的危险因素分别为心房颤动、入院时血糖、LDL-C、治疗时间在6h以后以及大面积梗死。结论:心房颤动、入院时血糖、LDL-C以及大面积梗死属于急性脑梗死后非溶栓患者出血转化的危险因素。Objective：To study the risk factors of hemorrhagic transformation in patients with acute cerebral infarction and to analyze the risk factors.Methods：96 patients with acute cerebral infarction after the thrombolysis in our hospital from June 2016 to December 2017 were selected as the research object.And they were divided into bleeding group 48 cases and hemorrhage transformation group 48 cases according to whether with hemorrhage occurs transformation.Then the lipid metabolism,atrial fibrillation,history of smoking and drinking,history of hypertension and diabetes,blood pressure,treatment time after onset and infarction area of two groups were compared,and the relationship between those factors and the disease were analyzed by the multi-factor Logistic regression analysis.Results：The atrial fibrillation,history of smoking and drinking of two groups had significant differences（P〈0.05）;The hospital fasting plasma glucose and LDL-C level of two groups had significant differences（P〈0.05）;the treatment time after onset and infarction area of two groups had significant differences（P〈0.05）;The multi-factor Logistic regression analysis showed that atrial fibrillation,blood glucose on admission,LDL-C and large area of infarction are the factors affecting the risk of bleeding in patients with acute cerebral infarction transformation.Conclusion：Atrial fibrillation,blood glucose on admission,LDL–C,treatment time after onset and large area of infarction belongs to the patients with acute cerebral infarction after the thrombolysis transformation of bleeding risk factors.

关 键 词：急性脑梗死 出血转化 影响因素 LOGISTIC回归分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]