妇科癌症患者认知功能损害及影响因素研究  

Prevalence and factors associated with cognitive impairment in women with gynecologic malignancies

作　　者：张扬 罗艳华 陆妃妃 曾迎春[2] 韩媛 Zhang Yang;Luo Yanhua;Lu Feifei;Zeng Yingchun;Han Yuan(School of Nursing, Guangzhou Medical University, Guangdong Guangzhou 510182, China;Obstetrics Department, the Third Affiliated Hospital of Guangzhou Medical University, Guangdong Guangzhou 510150, China)

机构地区：[1]广州医科大学护理学院,广东广州510182 [2]广州医科大学附属第三医院产科,广东广州510150

出　　处：《现代肿瘤医学》2018年第9期1396-1399,共4页Journal of Modern Oncology

基　　金：广东省医学科研基金项目(编号:A2015141)

摘　　要：目的:了解妇科癌症患者认知功能损害情况及分析其影响因素。方法:收集广州市某肿瘤医院妇科恶性肿瘤患者146例,同期按年龄、文化程度进行匹配,选取广州市三个社区的健康成年女性130例作为对照组。用中文版FACT-Cog量表、医院焦虑抑郁量表(HADS)、中文版简明疲劳量表(BFI-C)进行问卷调查。结果:研究组FACT-Cog总分为(108.81±24.54)分,对照组为(121.33±21.53)分,研究组在FACT-Cog总分及各维度(PCI、PCA、Other、QOL)得分均低于对照组,且在FACT-Cog总分、PCI、PCA方面差异有统计学意义(P<0.05);研究组认知障碍发生率为21.9%,健康对照组为8.5%。单因素分析结果显示,化疗、癌症分期、就业状态、焦虑和抑郁状况、疲劳与认知功能损害的发生有关(P<0.05)。多元线性回归分析结果显示,总体认知功能得分与化疗(β=-0.303,P<0.01)及抑郁(β=-0.449,P<0.01)呈负相关。结论:妇科癌症患者的认知障碍发生率较高,认知功能损害与化疗、焦虑、抑郁及疲劳存在相关性,化疗和抑郁是主要的危险因素。Objective： To evaluate the prevalence and risk associated with cognition in women with gynecologic malignancies. Methods： Case-control study was conducted among 146 patients with gynecologic malignancies and130 control subjects. Patients and control subjects were recruited from a tumor hospital and three communities in Guangzhou. They were queried using a functional assessment of cancer therapy-cognitive function（ FACT-Cog）,hospital anxiety and depression scale（ HADS）,Chinese version of the brief fatigue inventory（ BFI-C）. Results： The total score of FACT-Cog of study group was 108. 81 ± 24. 54. Control group was 121. 33 ± 21. 53. The scores of study group were lower than healthy controls in the FACT-Cog total score and each dimension（ PCI,PCA,Other,QOL）.There were significant differences between two groups in the scores of FACT-Cog,PCI,PCA（ P＜0. 05）. 21. 9% of patients had cognitive impairment in study group and healthy controls was 8. 5%. Single factor analysis results showed that chemotherapy,cancer stage,occupational status,anxiety,depression and fatigue were associated with perceived cognitive disturbances（ P＜0. 05）. Multiple linear regression analysis results showed that overall cognitive disturbances was associated with chemotherapy（ β =-0. 303,P＜0. 01） and depression（ β =-0. 449,P＜0. 01）. Conclusion： Study findings indicate that the incidence rate of cognitive impairment in patients with gynecologic malignancies is high. Chemotherapy,anxiety,depression and fatigue are associated with cognitive impairment. Chemotherapy and depression could be important factors contributing to the development of cognitive impairment.

关 键 词：妇科癌症 患者 认知障碍 影响因素 

分 类 号：R737.3[医药卫生—肿瘤]