吡喃阿霉素联合大剂量甲氨喋呤治疗淋巴系统恶性肿瘤的效果观察及对患者炎性因子水平的影响  

The Effect of Pirarubicin Combined with High Dose Methotrexate in the Treatment of Patients Lymphatic System Malignant Tumor and Influence on Inflammatory Factor Level

作　　者：郭莉[1] 丁珊珊[1] 梁霄[1] 李姗[1] 胡欣[1] GUO Li;DING Shanshan;LIANG Xiao;LI Shan;HU Xin(Department of Lymphoma, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, Chin)

机构地区：[1]新疆医科大学附属肿瘤医院淋巴瘤科,新疆乌鲁木齐830000

出　　处：《肿瘤药学》2018年第2期219-222,共4页Anti-Tumor Pharmacy

基　　金：新疆维吾尔自治区自然科学基金(2015211C121);新疆医科大学创新基金(XTC201150)

摘　　要：目的探究吡喃阿霉素联合大剂量甲氨喋呤治疗淋巴系统恶性肿瘤的效果及对患者炎性因子水平的影响。方法选取我院诊断为淋巴系统恶性肿瘤的60例患者作为研究对象,随机分为两组,对照组30例,采用大剂量甲氨蝶呤治疗,观察组30例,采用吡喃阿霉素联合大剂量甲氨蝶呤治疗。比较两组患者的临床治疗效果、并发症情况及炎性因子水平。结果观察组患者的临床治疗效果明显优于对照组(P<0.05);观察组患者化疗副反应的发生率明显低于对照组(P<0.05);治疗前两组患者炎性因子TNF-α和IL-4水平比较,差异无统计学意义(P>0.05),治疗后两组患者的炎性因子水平均降低,且观察组患者显著低于对照组(P<0.05);治疗后观察组患者的VAS评分显著低于对照组(P<0.05)。结论吡喃阿霉素联合大剂量甲氨喋呤治疗淋巴系统恶性肿瘤具有良好的治疗效果,可降低炎性因子水平,具有很大的临床实践价值。Objective To observe the effect of pirarubicin combined with high dose methotrexate in the treatment of lymphatic system malignant tumor and influence on inflammatory factor level of patients. Methods 60 lymphatic system malignant tumor patients were se-lected as the research objects in our hospital, and they were randomly divided into two groups. The control group was treated with high-dose methotrexate, while the experimental group was treated with pirarubicin combined with high-dose methotrexate. We observed the clinical therapeutic effect and the incidence of complications of patients in the two groups and compared the inflammatory factor levels of the two groups. Results The clinical treatment effect of the experimental group were significantly better than that of the control group （P〈0.05）; the incidence of the side effects of chemotherapy of the experimental group was significantly lower than that of the control group （P〈0.05）; the level of inflammatory factor TNF-α and IL-4 of the two groups before treatment were of no significant difference （P〉0.05）, the inflamma-tory factor levels of the two groups were both decreased after treatment, and the level of TNF-α and IL-4 of the experimental group were significantly lower than that of the control group （P〈0.05）; after treatment, the VAS score of the experimental group was lower than that of the control group （P〈0.05）. Conclusion Treating malignant tumor of the lymphatic system with pirarubicin combined with large doses of methotrexate can reduce the levels of inflammatory factors and has a good therapeutic effect. It is worthy of further promotion and application in clinical practice.

关 键 词：吡喃阿霉素 大剂量甲氨喋呤 淋巴系统恶性肿瘤 效果观察 炎性因子水平 

分 类 号：R733.4[医药卫生—肿瘤]