原发性口腔神经内分泌癌2例病例报告及文献回顾  

Primary neuroendocrine carcinoma of oral cavity: A report of two cases and literature review

作　　者：王丽[1] 任仪鹏[1] 贾婷婷[1] 席庆[1] 张明[1] 胡敏[1] 张海钟[1] WANG Li;REN Yipeng;JIA Tingting;XI Qing;ZHANG Ming;HU Min;ZHANG Haizhong(Department of Oral and Maxillofacial Surgery, Chinese PLA General Hospital, Beijing 100853, China)

机构地区：[1]解放军总医院口腔颌面外科,北京100853

出　　处：《解放军医学院学报》2018年第4期360-363,F0003,共5页Academic Journal of Chinese PLA Medical School

摘　　要：目的对口腔神经内分泌癌的临床表现、诊断、治疗及预后进行分析。方法对我院口腔颌面外科收治的2例典型原发于口腔的神经内分泌癌病例进行报告。结果 1例为60岁女性,上腭部小细胞型神经内分泌癌;另1例为74岁女性,下颌骨低分化神经内分泌癌。两例患者均进行了部分颌骨切除术及右侧颈部淋巴结清扫术,分别于术后20个月和术后38个月死亡。文献检索共发现口腔神经内分泌癌38例,男22例,女性患者16例。结论口腔神经内分泌肿瘤恶性程度高,易局部复发及远处转移,往往预后不良。Objective To analyze the clinical manifestation, diagnosis, treatment and prognosis of neuroendocrine carcinoma（NEC） in the oral cavity. Methods Two cases of primary NEC admitted to our hospital were reported, and related literatures were reviewed. Results Case No.1 was a 60-year-old women with primary neuroendocrine tumor of small cell type confirmed by histological and immunohistochemistry staining results. Case No.2 was a 74-year-old women with poorly differentiated primary NEC arising in the mandible. Both two cases had neck lymph node metastasis before diagnosis. Partial jaw resection and neck resection under general anesthesia were performed. Regrettable, the two patients died of NEC at 20 months and 38 months after surgery respectively. Conclusion NEC in the oral cavity is highly aggressive, often relapses locally and causes early distant metastasis with poor prognosis.

关 键 词：口腔神经内分泌癌 恶性肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]