组蛋白H3甲基化修饰与心脏发育的研究进展  

Progress in histone H3 methylation and heart development

作　　者：叶力通[1] 余细勇 刘旭东[1] 李振东[1] YE Li-tong;YU Xi-yong;LIU Xu-dong;LI Zheng-dong(Department of Pharmacy, Zhuhai Maternal and Child Care Center, Zhuhai 519000, China;Key Laboratory of Molecular Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University , Guangzhou 511436, China)

机构地区：[1]珠海市妇幼保健院药学部,广东珠海519000 [2]广州医科大学药学院分子临床药理学重点实验室,广东广州511436

出　　处：《中国病理生理杂志》2018年第5期950-955,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81120108003;No.81330007);国家973计划(No.2012 CB526600)

摘　　要：哺乳动物心脏发育需要干细胞的精确定位、增殖以及心肌祖细胞的分化等过程（[1]）,这一系列过程涉及到多个心脏目的基因的精确编程调控。心脏基因组装于致密的染色质结构中,而染色质的基本单位核小体主要是由147 bp碱基对组成的线性DNA盘绕于组蛋白八聚体外侧构成（[2]）。心脏目的基因的表达除了与基因序列相关外,还与心脏关键转录因子及基因组染色质结构修饰因子等表观遗传学途径密切相关。Congenital heart disease is one of the main types of birth defect. The mammalian heart developmental progress requires precise gene patterning in time and space. In addition to the gene sequence,recent research showed that the regulation of core cardiac gene expression has been proved to be closely related to cardiac transcription factors as well as the modification of genomic architecture of the histone. Methylation of histone might be the key nodes in the regulation of cardiac gene expression and chromatin structure. This review focuses on the role of histone H3 methylation in heart development process,which may lay a foundation for the prediction of epigenetic modification of congenital heart disease.

关 键 词：心脏 发育 组蛋白H3 甲基化 先天性心脏病 

分 类 号：R363[医药卫生—病理学] R541.1[医药卫生—基础医学]