Kluver-Bucy综合征4例临床分析  

Clinical analysis of Kluver-Bucy syndrome for 4 cases

作　　者：黄诚[1] 曹笃[1] 杨琴[1] 秦新月[1] HUANG Cheng;CAO Du;YANG Qin;QIN Xinyue(Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing 400016,China.)

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016

出　　处：《中国神经精神疾病杂志》2018年第2期95-99,共5页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的总结分析4例Kluver-bucy综合征(Kluver-bucy syndrome,KBS)临床表现、MRI特点、治疗及预后以提高临床医师对该综合征的认识。方法回顾性分析4例KBS患者的一般资料、主要症状、脑脊液及头颅MRI检查、治疗及预后,并行文献复习。结果 4例患者均在原发疾病病程中出现KBS,主要症状为温顺、饮食习惯改变、性欲亢进、思维奔逸、口欲亢进、视觉失认。头颅MRI为原发疾病表现,即双侧海马、颞叶、岛叶、额叶、扣带回受累。3例给予卡马西平联合氟西汀及抗精神病药物治疗后完全缓解,1例症状自发消失,随访6~12个月无复发。结论 KBS多以食欲亢进为首发症状,头颅MRI为原发疾病特征且对诊断有重要价值,经抗癫痫、抗精神病等药物治疗预后良好。Objective To improve the clinicians＇ awareness of Kluver-bucy syndrome（KBS）, we retrospectively analyzed 4 cases of KBS such as clinical manifestation, MRI feature, treatment and prognosis. Methods We performed a retrospective analysis on 4 cases of KBS including general clinical data, key clinical symptoms, findings from cerebrospinal fluid and Cranial MRI examination, treatment strategy and prognosis, and literature review. Results All four patients showed KBS in the course of primary disease. The clinical symptoms of KBS mainly presented as gentle,indiscriminate dietary behavior, hypersexuality, hypermetamorphosis, hyperorality and visual agnosia. MRI Showed primary disease-associated alterations in diverse brain regions including hippocampus, the temporal lobe, the insula, the frontal lobe, and the cingulate gyrus. Three cases achieved completely clinical remission after treatment with carbamazepine, fluoxetine and antipsychotic drugs. One patient＇s symptoms disappeared spontaneously and no recurrence of symptoms was observed in the following 6 -12 months. Conclusion Bulimia is often the first symptom of KBS.Cranial MRI is the characteristic of the primary disease and has great diagnostic value. Treatment with antiepileptic and antipsychotics can achieve favorable prognosis.

关 键 词：Kluver-Bucy综合征 主要症状 头颅MRI 治疗 预后 

分 类 号：R749.1[医药卫生—神经病学与精神病学]