HE4与慢性心力衰竭患者心功能的相关性  

Correlation between HE4 and cardiac function in chronic heart failure patients

作　　者：曹建红[1] 刘怡[1] 唐荣萍 徐春华 兰琴[1] 范慧敏[1] CAO Jian-hong;LIU Yi;TANG Rong-ping;XU Chun-hua;LAN Qin;FAN Hui-min(Dept. of Heart Failure, East Hospital, Tongji University, Shanghai 200120, China)

机构地区：[1]同济大学附属东方医院心力衰竭专科,上海200120

出　　处：《同济大学学报（医学版）》2018年第2期94-98,共5页Journal of Tongji University(Medical Science)

基　　金：上海市卫计委课题(201440046);同济大学附属东方医院朝阳人才计划(DFZY-17)

摘　　要：目的探讨慢性心力衰竭患者HE4水平与心功能的关系。方法选取因慢性心力衰竭住院的200例患者为研究对象,平均年龄(71.81±12.49)岁。将心功能Ⅰ-Ⅱ级定义为心功能不全低危组,将心功能Ⅲ-Ⅳ级定义为心功能不全高危组。多因素Logistic回归分析评估导致慢性心力衰竭发生的危险因素。结果 BMI、HDL-C等指标心功能不全高危组与心功能不全低危组组间差异无统计学意义(P≥0.05);而LDL-C、CRP、HE4、UA等指标两组间差异有统计学意义(P<0.05)。当调节变量包括年龄、性别、HE4以及NT-pro BNP时,HE4和NT-pro BNP是与慢性心力衰竭患者心功能密切相关的危险因素。而当调节变量包括年龄、性别、HE4、NT-pro BNP、吸烟、饮酒、HDL-C、LDL-C以及UA时,结果提示性别、HE4和NT-pro BNP是与慢性心力衰竭患者心功能密切相关的危险因素。结论性别、HE4和NT-pro BNP是与慢性心力衰竭患者心功能密切相关的危险因素,慢性心力衰竭患者HE4水平与心功能的分级存在相关关系。Objective To investigate the relationship between human epididymis protein 4（ HE4） level and cardiac function in chronic heart failure patients. Methods Two hundred patients aged 71. 81±12. 49 years with chronic heart failure admitted in hospital were enrolled in the study. Patient were divided into lowrisk heart failure group（ grade Ⅰ-Ⅱ） and high risk heart failure group（ grade Ⅲ-Ⅳ）. The risk factors of chronic heart failure were analyzed with Logistic regression. Results There were no significant differences in BMI and HDL-c between two groups（ P ≥0. 05）,while there were significant differences in LDL-C,CRP,HE4 and UA between two groups（ P〈0. 05）. HE4 and NT-pro BNP were independent risk factors for predicting cardiac insufficiency. The gender,HE4 level and NT-pro BNP were independent risk factors of cardiac dysfunction when age,sex,HE4,NT-pro BNP,smoking,drinking,HDL-C,LDL-C and UA were adjusted. Conclusion Gender, HE4 and NT-pro BNP are independent risk factors of cardiac insufficiency,and HE4 levels are associated with the classification of cardiac function in chronic heart failure patients.

关 键 词：人附睾蛋白(human EPIDIDYMIS PROTEIN 4 HE4) 慢性心力衰竭 危险因素 

分 类 号：R541.61[医药卫生—心血管疾病]