急性脑梗死患者血清CXCL4和CXCL12与颈动脉斑块稳定性的关系  

Relation between CXCL4、CXCL12 and stable carotid atherosclerotic plaques in serum ofpatients with acute ischemic cerebral stroke

作　　者：李娜[1] 梁蔚骏[2] 胡为民[2] 刘东星 常艳芳 Li Na;LIANG Weijun;HU Weimin;LIU Dongxing;CHANG Yanfang(Shanxi Medical University, Taiyuan 030001, China;The Second Hospital of Shanxi Medical University, Taiyuan 030001, China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2018年第5期326-332,共7页Proceeding of Clinical Medicine

摘　　要：目的:探讨急性脑梗死患者血清血小板源性趋化因子CXCL4、CXCL12水平与颈动脉粥样硬化斑块稳定性的关系。方法:选择2017年2月—2017年11月收治的70例急性脑梗死患者为观察组,采用彩色多普勒超声仪测量颈动脉斑块,将观察组分为无斑块组(11例),稳定斑块组(40例)和不稳定斑块组(19例)。选取年龄、性别与观察组相匹配的同时期无脑血管病表现者65例为对照组。采用双抗体夹心酶联免疫吸附法(ELISA)测定两组血清CXCL4、CXCL12表达水平,并对检查结果进行比较。结果:观察组发病72 h内血清CXCL4、CXCL12水平显著高于对照组,差异有统计学意义(P<0.01);观察组内不稳定斑块组血清CXCL4、CXCL12水平显著高于无斑块组和稳定斑块组,差异有统计学意义(P<0.05);血清CXCL4、CXCL12与颈动脉粥样硬化斑块稳定性之间存在明显的相关性,差异有统计学意义(P<0.05);血清CXCL4与CXCL12水平之间有明显的相关性(r=0.466,P<0.05)。结论:血清CXCL4、CXCL12水平在脑梗死发病72 h内显著升高,提示二者可能参与了急性脑梗死的发生;血清CXCL4、CXCL12水平与动脉粥样硬化斑块的稳定性密切相关,可能成为不稳定性粥样硬化斑块的独立预测指标;血清CXCL4与CXCL12水平之间存在显著相关性,提示二者对颈动脉粥样硬化不稳定斑块的形成及脑梗死的发生具有协同促进作用。Objective： To investigate the levels ofplatelet-derived chemokines CXCL4 and CXCL12 in serum of patients with ischemic cerebrovascular disease,andrelationship with the carotid atherosclerotic plaques. Methods： All 70 patients with ischemic cerebrovascular disease were selected as the research group who had been hospitalized in neurology department in our hospital from February 2017 to November 2017. According to the application of color Doppler ultrasound,all subjects were divided into non plaque group（ 11 cases）,stable plaque group（ 40 cases） and unstable plaque group（ 19 cases）. At the same time,65 physical examination patients were collected whose indicators such as age,gender are comparable with the research groups as the control group who were diognised no cerebral vascular disease. Then the levels of CXCL12 in serum of patients in the two groups were detected by the ELISA method,and the results were compared and analyzed. Results： Compared with control group,plasma CXCL4 and CXCL12 levels of cerebral infarction group were obviously higher,differences was statistically significant（ P〈0. 05）. There was significant difference in the research group for Patients with three different types of levels of plaque CXCL12 in serum（ P〈0. 05）. In cerebral infarction group,unstable plaque group have a significantly higher levels of plasma CXCL12 than no plaque group（ P〈0. 05） and stable plaque（ P〈0. 05）. There is a significant correlation between serum CXCL 4,CXCL 1 2 and the stability of carotid atherosclerotic plaque and differences was statistically significant（ P〈0. 05）. There is a significant correlation between CXCL4 and CXCL12 in the serum and differences was statistically significant（ r = 0. 466,P〈0. 05）. Conclusion： The level of serum CXCL4 and CXCL12 increased significantly within 72 hours of the onset of cerebral infarction,suggesting that the two may be involved in the occurrence of acute cerebral infarction. The levels of serum CXCL4 and CXCL12 are close

关 键 词：急性脑梗死 趋化因子CXCL4、CXCL12 颈动脉粥样硬化 颈动脉斑块稳定性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]