丁苯酞序贯治疗老年急性脑梗死的疗效以及对血脂、血清脂联素的影响  

Effect of Sequential Therapy with Butylphthalide on Blood Lipid and Serum Adiponectin in Elderly Patients with Acute Cerebral Infarction

作　　者：王丽平[1] 张磊[1] WANG Li- ping;ZHANG Lei(Department of Geriatrics, the First Affiliated Hospital of Chengdu Medical College, Chengdu,610500, China)

机构地区：[1]成都医学院第一附属医院老年医学科,成都610500

出　　处：《血栓与止血学》2018年第2期207-210,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的观察丁苯酞序贯治疗老年急性脑梗死的疗效以及对血脂、血清脂联素的影响。方法将360例急性脑梗死患者随机分为常规组和序贯组,每组180例,常规组给予抗凝、降脂、降压等对症治疗,序贯组在常规组治疗的基础上,配合丁苯酞序贯治疗。两组均治疗4周。比较两组治疗前后NIHSS、ADL评分,血清炎性因子TNF-α、IL-8水平,血脂、血流流变学、脂联素水平以及治疗疗效。结果研究结果显示,两组治疗后NIHSS评分较治疗前显著降低,序贯组治疗后NIHSS评分显著低于常规组(P<0.05),两组治疗后ADL评分较治疗前显著升高,序贯组治疗后ADL评分显著高于常规组(P<0.05)。两组治疗后血清炎性因子TNF-α、IL-8水平较治疗前显著下降,序贯组治疗后血清炎性因子TNF-α、IL-8水平显著低于常规组(P<0.05)。两组治疗后胆固醇及甘油三酯等血脂指标较治疗前显著下降,血小板聚集率及血浆粘度显著降低,脂联素水平显著升高(P<0.05),组间比较,序贯组血脂及血流指标显著低于常规组,脂联素水平显著高于常规组(P<0.05)。序贯组治疗有效率为91.11%,显著高于常规组的83.89%(P<0.05)。结论丁苯酞序贯法可有效地改善老年急性脑梗死的神经功能缺损,提高生存质量,改善血流流变学指标,调整血脂及炎性因子水平的异常。Objective To observe the effect of sequential therapy with butylphthalide in elderly patients with acute cerebral infarction and its effects on blood lipids and serum adiponectin levels. Methods 360 cases of acute cerebral infarction were randomly divided into routine group and sequential group, 180 cases in each group, the conventional group received anticoagulation, lowering blood pressure and other symptomatic treatment, the sequential group based on routine treatment group, combined with butylphthalide sequential therapy. The two groups were treated for 4 weeks. NIHSS, ADL scores, serum inflammatory factors, TNF-α and IL-8 levels, blood lipids, blood rheology, adiponectin levels and therapeutic efficacy were compared between the two groups before and after treatment. Results The results showed that the two groups of NIHSS score after treatment were significantly lower than that before treatment, the sequential group NIHSS score after treatment was significantly lower than normal group （ P 〈 0. 05 ）, the two groups after treatment ADL score was significantly higher than that before treatment, the sequential group ADL score after treatment was significantly higher than normal group （ P 〈 0. 05 ）. The levels of serum inflammatory factors TNF- α and IL- 8 in the two groups were significantly lower than those before treatment. The serum levels of inflammatory factors TNF-α and IL- 8 in the sequential group were significantly lower than those in the conventional group （ P 〈 0. 05 ）. The two groups after treatment of cholesterol and triglyceride lipid index decreased significantly compared with before treatment,the platelet aggregation rate and plasma viscosity decreased significantly, adiponectin levels increased significantly（ P 〈 0. 05 ）, comparison between groups, and blood lipid index sequential group was significantly lower than normal group, adiponectin level was significantly higher than normal group （ P 〈 0. 05 ）. The effective rate of the sequential group was 91.11% ,which

关 键 词：丁苯酞 急性脑梗死 血清脂联素 血脂 

分 类 号：R743[医药卫生—神经病学与精神病学]