VEGF和CD31在子宫内膜样腺癌中的表达及其临床意义  

Expression and Clinical Significance of VEGF and CD31 in Eddometriod Carcinoma

作　　者：夏秀红 范江涛[1] 李莉莉[1] 陈红燕[1] XlA Xiuhong;FAN Jiangtao;LI Lili;et al(The First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi 530021, China)

机构地区：[1]广西医科大学第一附属医院,广西南宁530021

出　　处：《实用妇产科杂志》2018年第4期282-286,共5页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金(编号:81360388);广西自然科学基金(编号:2016 GXNSFAA380258)

摘　　要：目的:检测血管内皮生长因子(VEGF)和CD31在不同子宫内膜组织中的表达情况。方法:采用免疫组化方法检测VEGF、CD31在52例子宫内膜样腺癌组织、22例子宫内膜不典型增生组织及21例正常子宫内膜组织中的表达,对结果进行量化分析。结果:(1)VEGF在正常子宫内膜组织、不典型增生组织及子宫内膜样腺癌中表达的阳性率分别为23.8%、31.8%、65.4%;CD31在正常子宫内膜组织、不典型增生组织及子宫内膜样腺癌组织中标记的微血管密度(microvessel density,MVD)分别为23.6±11.7、31.5±17.7、51.9±21.1。VEGF的阳性表达及CD31-MVD(CD31标记的MVD)在子宫内膜样腺癌组织中明显高于不典型增生及正常子宫内膜组织(P<0.05)。(2)VEGF在子宫内膜样腺癌中的表达,与淋巴结转移有关(P<0.05)。CD31-MVD与肿瘤分期、浸润肌层深度、组织学类型有关(P<0.05)。(3)在子宫内膜样腺癌组织,VEGF表达与CD31-MVD无明显相关性(r=0.095,P=0.504)。结论:VEGF表达、CD31-MVD在子宫内膜样腺癌组织中增高,可能促进子宫内膜样腺癌的发生发展及转移浸润。Objective：To explore the expression of VEGF,CD31 in endometriod carcinoma. Methods：Expres- sion levels of VEGF and CD31 in 52 cases of endometriod carcinoma,22 cases of atypical hyperplasia and 21 ca- ses of normal endometrium tissues were analyzed by immunohistochemistry,and the blood vessels stained with CD31 were counted. Results：（1）The positive rate of VEGF expression in normal endometrium,atypical hyperplasi- a and endometriod carcinoma was 23, 8% ,31.8% ,65.4% respectively. The CD31 - MVD was significantly differ- ent in normal endometrium, atypical hyperplasia and endometrial carcinoma, which were 23. 6 ± 11.7,31.5 ± 17. 7,51.9 ±21.1 respectively. （2）The expression of VEGF was correlated with lymphatic metastasis（ P〈0. 05）. The CD31 -MVD was correlated with tumor stage, myometrial invasion and histological grade （P 〈 0.05）. （3）There was no correlation of VEGF and CD31 expression in endometriod carcinoma tissues （ r = 0. 095, P = 0. 504）. Conclusions：The over-expression of VEGF and CD31 may participate in angiogenesis of endometriod carcinoma, This research shows that they have clinical value as the tumor markers of endometriod carcinoma,

关 键 词：子宫内膜样腺癌 血管生成 血管内皮生长因子 CD31 

分 类 号：R737.33[医药卫生—肿瘤]