NHL患者血清IL-21的表达及临床意义  

Expression and clinical significance of serum IL-21 in patients with non-Hodgkin's lymphoma

作　　者：陈迪 杨敏[1] 任明强[1] 陈琦[1] CHEN Di;YANG Min;REN Ming-qiang;CHEN Qi.(Department of Hematology, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHIN)

机构地区：[1]遵义医学院附属医院血液内科,贵州遵义563000

出　　处：《海南医学》2018年第8期1111-1113,共3页Hainan Medical Journal

摘　　要：目的检测非霍奇金淋巴瘤(NHL)患者血清中白细胞介素21(IL-21)的表达水平,探索IL-21与NHL的发病及预后的相关性。方法选择2015年12月至2016年12月遵义医学院附属医院收治的NHL患者36例(初诊患者20例,化疗后患者16例),以同期13例健康志愿者为对照组,应用酶联免疫吸附试验(ELISA)检测NHL患者治疗前后和对照组人群的血清IL-21水平,比较初诊NHL患者血清IL-21水平在年龄、性别、分期、分组、有无结外浸润等临床因素有无差异,分析治疗前后NHL患者血清IL-21水平的变化。结果 NHL患者血清IL-21水平为(200.75±58.91)ng/L,明显低于对照组的(420.91±132.56)ng/L,差异具有统计学意义(P<0.05);初诊NHL处于Ⅲ期和Ⅳ期患者血清IL-21水平为(153.77±25.97)ng/L,明显低于Ⅰ期和Ⅱ期患者的(223.87±35.36)ng/L,差异具有统计学意义(P<0.05);有全身症状者血清IL-21水平为(141.15±17.95)ng/L,明显低于无全身症状者的(208.46±33.50)ng/L,差异具有统计学意义(P<0.05);有结外浸润者血清IL-21水平为(143.94±19.38)ng/L,明显低于无结外浸润者的(212.53±32.80)ng/L,差异具有统计学意义(P<0.05);治疗前患者血清IL-21水平为(162.63±38.75)ng/L,明显低于治疗缓解后患者的(264.45±43.89)ng/L,差异具有统计学意义(P<0.05)。结论 IL-21表达水平与NHL的分期、分组、有无结外浸润有关,IL-21的表达水平可能与NHL的发病及预后有关。Objective To investigate the expression and clinical significance of serum interleukin-21（IL-21）in patients with non-Hodgkin＇s lymphoma（NHL）. Methods A total of 36 patients with NHL admitted to Department of Hematology of the Affiliated Hospital of Zunyi Medical University from December 2015 to December 2016 were selected as the research subjects, including 20 initially diagnosed patients and 16 patients after chemotherapy. Meantime, 13 healthy volunteers were enrolled as the control group. The levels of IL-21 in serum were determined by enzyme-linked immunosorbent assay（ELISA） to investigate its relationship with age, sex, stage, grouping, with or without internal and external organ infiltration and other clinical factors. The serum IL-21 levels changes in patients with NHL before and after chemotherapy were analyzed. Results The levels of IL-21 in NHL patients was lower than those in controls,（200.75±58.91） ng/L vs（420.91±132.56） ng/L, P〈0.05. Compared with newly diagnosed NHL patients of stage Ⅰ andⅡ, the levels of IL-21 decreased markedly in patients of stage Ⅲ and Ⅳ,（153.77±25.97） ng/L vs（223.87±35.36） ng/L,P〈0.05. The levels of IL-21 in patients with systemic symptoms were significantly lower than those without systemic symptoms,（141.15±17.95） ng/L vs（208.46±33.50） ng/L, P〈0.05. Moreover, compared with infarcted organ infiltration group, the content of IL-21 declined significantly in extranodal organ infiltration group：（143.94±19.38） ng/L vs（212.53±32.80） ng/L, P〈0.05. The serum IL-21 level in patients with NHL after treatment remission was significantly higher than that of NHL before treatment：（264.45±43.89） ng/L vs（162.63±38.75） ng/L, P〈0.05. Conclusion The expression level of serum IL-21 is related to the staging, grouping and extranodal invasion of NHL. The level of serum IL-21 may be associated with the pathogenesis and prognosis of NHL.

关 键 词：非霍奇金淋巴瘤 白细胞介素21 表达 酶联免疫吸附试验 

分 类 号：R733.4[医药卫生—肿瘤]