提高抗肿瘤血管生成治疗的方法  

Methods to improve the treatment of antitumor angiogenesis

作　　者：张百红[1] 岳红云[2] ZHANG Baihong;YUE Hongyun(Department of Oncology;Department of Ophthalmology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, Gansu Province, China)

机构地区：[1]兰州军区兰州总医院肿瘤科,甘肃兰州730050 [2]兰州军区兰州总医院眼科,甘肃兰州730050

出　　处：《肿瘤》2018年第4期386-391,共6页Tumor

基　　金：甘肃省自然科学基金资助项目(编号:1308RJZA181)~~

摘　　要：血管新生是肿瘤的重要特征,在肿瘤细胞的生长和迁移过程中发挥重要作用。血管生成已成为肿瘤药物治疗的重要靶标,控制血管生成的调节分子和信号分子已成为研究热点。血管生成抑制剂通过阻断肿瘤血管供应,在给众多患者带来生存获益的同时,也可能促进肿瘤进展和治疗耐受。寻找新的策略可能提高抗肿瘤血管生成治疗的效果,包括调节血管拟态、肿瘤血管正常化、寻找预测因子、开发多靶点药物和联合治疗模式等。增加肿瘤氧供应和血液灌注也可提高肿瘤血管生成治疗的效果。Abnormal vessel and function are hallmarks of cancer, and they contribute to cancer progression and migration. Angiogenesis has become an attractive target for drug therapy, and several regulatory and signaling molecules governing angiogenesis are of interest. Angiogenesis inhibitors, intending to block tumor＇s blood supply and provide survival benefits for cancer patients, may fuel tumor progression and treatment resistance. Actionable strategies to improve clinical efficacy of angiogenesis inhibitors include vascular mimicry regulation, tumor vessel normalization, seeking predictive factors, multi-targeted drugs development and combinational therapeutics. Moreover, strategies aiming at alleviating tumor hypoxia while improving perfusion may enhance the outcome of antiangiogenic therapy. Angiogenesis inhibitors offer an avenue for the development of cancer therapy.

关 键 词：肿瘤 血管生成抑制剂 血管正常化 药物联合治疗 

分 类 号：R730.53[医药卫生—肿瘤]