阿瑞吡坦治疗高致呕性化疗药物患者的影响及护理  

The effect of aprepitant for the patients underwent high emetogenic chemotherapy drugs and nursing care

作　　者：陈丽东[1] 黄丽萍[1] 尤雪香 李少莹 CHEN Li-dong;HUANG Li-ping;YOU Xue-xiang;LI Shao-ying(Department of No. 1 Internal Medicine, Cancer Hospital Affiliated to Medical College of Shantou University, Shantou Guangdong Province 515000, China)

机构地区：[1]汕头大学医学院附属肿瘤医院内一科,广东汕头515000

出　　处：《中国城乡企业卫生》2018年第4期8-10,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的探讨阿瑞吡坦对于治疗高致呕性化疗药物的患者生活质量的影响及护理措施。方法选取2016年2月-2017年5月汕头大学医学院附属肿瘤医院134例化疗患者为研究对象,根据入院顺序将入组的患者分为对照组和研究组,每组67例,对照组患者化疗的同时应用托烷司琼与地塞米松治疗,研究组患者在对照组的基础上联合应用阿瑞吡坦治疗,比较两组患者恶心呕吐发生率及干预前后患者的生活质量变化。结果研究组及对照组患者恶心呕吐发生率为28.36%、77.61%,差异有统计学意义(P<0.05),干预前两组患者的各生活质量评分比较,差异无统计学意义(P>0.05),干预后两组患者的各生活质量评分均显著提高,且研究组优于对照组,差异有统计学意义(P<0.05)。结论对应用高致呕性化疗药物的患者采用阿瑞吡坦进行治疗,并配合相应的护理措施有助于减少患者恶心呕吐的发生率,提高生活质量,具有重要的临床应用价值。Objective To investigate the effect of aprepitant for the life quality of patients underwent high emetogenic chemotherapy drugs and nursing measures. Methods From FebruaPy 2016 to May 2017, 134 cases of chemotherapy patients in Cancer Hospital Affiliated to Medical College of Shantou University were selected as the research objects. According to the order of admission, the patients were divided into the control group and the study group, 67 cases in each group. At the time of chemotherapy, the control group was given tropisetron and dexamethasone treatment, the study group was given aprepitant on the basis of the control group. The incidence of nausea and vomiting and the quality of life of patients before and after intervention were compared between the two groups. Results The incidence of nausea and vomiting in the study group and the control group were 28.36% and 77.61%, there was statistical difference between the two groups （P〈0.05）. Before intervention, there was no significant difference in the quality of life scores between the two groups （P〉0.05）. After intervention, the quality of life scores of the two groups were significantly improved, and the study group was better than that of the control group（P〈0.05）. Conclusion The application of high vomiting chemotherapy drugs with aprepitant for treatment and nursing measures can help to reduce the incidence of nausea and vomiting, improve the quality of life. It has important clinical value.

关 键 词：阿瑞吡坦 高致呕性化疗药物 生活质量 护理措施 

分 类 号：R73[医药卫生—肿瘤]