补虚健脾法对大肠癌术后脾虚证疗效及对免疫功能的临床研究  

Therapeutic effects on spleen deficiency after operation in large intestine cancer and the clinical research on immune function treated with the therapy for reinforcing deficiency and strengthening the spleen

作　　者：王歌[1] 白龙[1] 王素娟[1] 王国力[2] WANG Ge;BAI Long;WANG Su -juan;WANG Guo- li(Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang Liaoning 110101;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang Liaoning 110032)

机构地区：[1]辽宁中医药大学附属四院,辽宁沈阳110101 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《世界中西医结合杂志》2018年第3期399-402,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察补虚健脾法对大肠癌术后脾虚证疗效及对免疫功能的影响。方法将肠癌根治性手术后的120例患者随机分成补虚健脾法治疗组和对照组各60例。对照组给予静脉化疗、补液、营养支持等常规治疗方法;补虚健脾法治疗组在常规治疗基础上给予补虚健脾的中药,治疗4周后,观察治疗前后两组患者的中医症状评分、KPS评分、免疫细胞亚群、细胞因子。结果在中医症状疗效方面,治疗组的总有效率为88.33%,对照组的总有效率为63.33%,治疗组疗效优于对照组(P<0.05)。在中医症候评分及KPS评分方面,治疗后两组均有改善,治疗组疗效优于对照组(P<0.01)。而在免疫细胞亚群及细胞因子方面,治疗后两组可以显著提高CD3^+、CD4^+、CD4^+/CD8^+、NK细胞、IL-2、IL-4的水平,同时降低CD8^+T细胞、TNF-α的水平,且治疗组疗效优于对照组(P<0.05)。结论补虚健脾法可改善大肠癌术后的临床症状,调节免疫因子及功能,进而提高患者生活质量,可用于大肠癌术后患者的维持治疗。Objective To observe the therapeutic effects on spleen deficiency after operation in large intestine cancer and the impacts on immune function treated with the therapy for reinforcing deficiency and strengthening the spleen. Methods A total of 120 patients after radical operation of cancer were randomized into a treatment group and a control group,60 cases in each one. In the control group,the conventional treatment was used,including intravenous chemotherapy,fluid infusion and nutrition support. In the treatment group,on the base of the treatment as the control group,the Chinese herbal medicine for reinforcing deficiency and strengthening the spleen was added. After 4-week treatment,TCM symptom score,KPS score,immune cell subset and cellular factors were observed before and after treatment in the patients. Results Regarding the effects on TCM symptoms,the total effective rate was 88. 33% in the treatment group and was 63. 33% in the control group. The effects in the treatment group was better than the control group（ P〈0. 05）. TCM symptom score and KPS score were all improved. The improvements in the treatment group were better than the control group（ P〈0. 01）. Regarding the immune cell subset and cellular factors,the levels of CD3~＋,CD4~＋,CD4~＋/CD8~＋,NK cells,IL-2 and IL-4 were improved significantly. The levels of CD8~＋T cells and TNF-α were reduced. The effects in the treatment group were better than the control group（ P〈0. 05）. Conclusion The regimen for reinforcing deficiency and strengthening the spleen relieves the clinical symptoms,regulates the immune factors and functions and improves the living quality in the patients.This therapy is applicable for the maintenance treatment in the patients after operation of large intestine cancer.

关 键 词：大肠癌术后 补虚健脾法 免疫功能 

分 类 号：R735.34[医药卫生—肿瘤]