Vitamin D in prostate cancer  

作　　者：Donald L Trump Jeanny B Aragon-Ching 

机构地区：[1]Inova Schar Cancer Institute, Inova Health System, Fairfax, VA 22037, USA.

出　　处：《Asian Journal of Andrology》2018年第3期244-252,共9页亚洲男性学杂志（英文版）

摘　　要：Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.

关 键 词：ANDROGENS CYP24A1 INFLAMMATION prostate cancer vitamin D analogs 

分 类 号：S816.7[农业科学—饲料科学] Q959.837[农业科学—畜牧学]