特发性视神经炎相关动物模型的研究进展  

Research progression of animal models of idiopathic optic neuritis

作　　者：张榆欣 杨晖[1] Zhang Yuxin;Yang Hui. State Key(Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China)

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060

出　　处：《中华眼科杂志》2018年第4期316-320,共5页Chinese Journal of Ophthalmology

基　　金：广东省自然科学基金（2017A030313610）

摘　　要：特发性视神经炎（ON）是发生在视神经的特发性炎性反应疾病，以多发性硬化相关视神经炎（MS-ON）和视神经脊髓炎相关视神经炎（NMO-ON）最为常见。由于ON发病机制不明，目前尚无确切有效的治疗措施。动物模型对研究疾病的发病机制具有重要作用，而随着对ON病因和发病机制的了解，新的ON动物模型正在研发中。本文总结和分析MS-ON和NMO-ON动物模型的研究进展，并简述ON动物模型的形态和功能评价指标的发展，以期为临床相关工作提供参考。Idiopathic optic neuritis （ON） is an idiopathic inflammatory disease of the optic nerve. The two most common types of ON are multiple sclerosis related ON and neuromyelitis optica related ON. But so far the precise mechanisms of different types of ON have been unclear and treatments are not satisfactory. Animal disease models play critical roles in the disease mechanism research. On the other hand, with more understanding about the etiology and mechanism of ON, new models mimicking different types of ON are under development. This article reviews the recent research progression of animal models of multiple sclerosis related ON and neuromyelitis optica related ON and the model evaluation methods.

关 键 词：视神经炎 疾病模型 动物 多发性硬化 视神经脊髓炎 

分 类 号：R-332[医药卫生] R774.61