宫颈癌同步放化疗患者抑郁状况及其影响因素  

Depression status and its influencing factors in the patients with cervical cancer undergoing concurrent chemoradiotherapy

作　　者：杨英珍 袁亚萍[1] 吕银 潘发明[1] YANG Ying-zhen;YUAN Ya-ping;LU Yin;PAN Fa-ming(School of Public Health ,Medical University of Anhui, Hefei 230032 ,P. R. China;Department of Radiotherapy ,First Affiliated Hospital of Medical University of Anhui ,He f ei 230022,P. R. China)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]安徽医科大学第一附属医院放疗科,安徽合肥230022

出　　处：《中华肿瘤防治杂志》2017年第23期1619-1623,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：安徽省高校自然科学重大项目(KJ2016SD26)

摘　　要：目的中晚期宫颈癌患者治疗依从性差,易产生失眠、脱发、恶心呕吐和抑郁等不良反应。本研究调查同步放化疗治疗宫颈癌患者抑郁现状,分析其影响因素。方法运用一般情况调查表、贝克抑郁自评量表、家庭关怀指数问卷和社会支持量表,采用便利抽样方法对2016-08-01-2017-05-30合肥市3所三级甲等医院217例宫颈癌同步放化疗患者进行问卷调查。结果所有患者抑郁得分(20.93±8.81)分,抑郁检出率为70.5%。家庭关怀指数总分为(7.75±2.04)分,家庭关怀指数总分及各维度得分与抑郁得分呈负相关,r值范围为-0.428^-0.298,均P<0.01。社会支持总分为(36.78±6.65)分,社会支持总分及各维度得分与抑郁得分也呈负相关,r值范围为-0.453^-0.265,均P<0.01。单因素分析显示,家庭关怀、社会支持、家庭月收入、诊断分级、年龄、治疗方式和医护人员健康教育指导次数均是患者抑郁的影响因素,差异均有统计学意义,均P<0.05。结论宫颈癌同步放化疗患者抑郁情况严重,医护人员应高度重视,针对影响因素,提出干预措施。OBJECTIVE Patients with advanced cervical cancer behave poor treatment compliance,are prone to adverse reactions,such as insomnia,alopecia,nausea and vomiting,depression,and so on.This study investigated the current status of depression in patients with cervical cancer received concurrent chemoradiotherapy and analyzed their influencing factors.METHODS A convenience sampling method was conducted to investigate the 217 patients with cervical cancer who received concurrent chemoradiotherapy from August 1,2016 to May 30,2017 in three class-3 first level hospitals in Hefei city using general situation questionnaire,family care index questionnaire（PAGAR）,social support scale（SSRS）and Beck＇s self-rating depression scale（BDI）.RESULTS Depression score was（20.93±8.81）.The incidence of depression was 70.5% .Family PAGAR index score was（7.75±2.04）.The total score of family PAGAR index and the scores of each dimension were negatively correlated with the scores of depression（r was from-0.428 to-0.298,P〈0.01）.The total score of social support total score was（36.78±6.65）.The total score of social support and the scores of each dimension were negatively correlated with the scores of depression（r was from-0.453 to-0.265,P〈0.01）.Single factor analysis showed that family care,social support,family income,diagnostic grade,age,treatment,the number of medical staff health education guidance were all influencing factors for depression.The differences were statistically significant（P〈0.05）.CONCLUSIONS Medical staff should attach great importance to the depression in patients with cervical cancer undergoing concurrent chemoradiotherapy.The intervention measures should be taken according to the influencing factors.

关 键 词：宫颈癌 同步放化疗 抑郁 影响因素 

分 类 号：R737.33[医药卫生—肿瘤] R749.4[医药卫生—临床医学]