卡培他滨节拍化疗在老年转移性乳腺癌维持治疗中的临床疗效  

Clinical efficacy of capecitabine metronomic chemotherapy in elderly patients with metastatic breast cancer

作　　者：贺艳[1] 周泽强[1] 李伟[1] 彭小花[1] breast cancer HE Yah;ZHOU Ze-qing;LI Wei;PENG Xiao-hua(Department of Oncology, the Second People＇s Hospital of Shenzhen , Shenzhen 518000, China)

机构地区：[1]深圳市第二人民医院肿瘤科,深圳市518000

出　　处：《实用老年医学》2018年第4期327-329,334,共4页Practical Geriatrics

摘　　要：目的探讨卡培他滨节拍化疗在老年转移性乳腺癌维持治疗中的临床疗效。方法选择2014年12月至2015年12月我科收治的老年转移性乳腺癌病人40例,随机分为节拍化疗组和常规化疗组,每组20例。节拍化疗组给予小剂量卡培他滨500 mg,2次/d,持续口服;常规化疗组给予卡培他滨1250 mg,2次/d,连续口服14d,休7 d,21 d为1个疗程,2个疗程后进行临床疗效、不良反应和生活质量评价。结果节拍化疗组的有效率(RR)(25.0%)和控制率(DCR)(90.0%)与常规化疗组的RR(30.0%)和DCR(85.0%)相比,差异无统计学意义(P>0.05);节拍化疗组均未见Ⅲ和Ⅳ级不良反应,常规剂量组手足综合征、骨髓抑制和消化道反应发生率及严重程度均显著高于节拍化疗组(P<0.05);节拍化疗组生活质量改善显著优于常规化疗组(P<0.05)。结论卡培他滨节拍化疗在老年转移性乳腺癌病人维持治疗中的临床疗效与常规剂量维持治疗相当,同时可以减轻病人的不良反应,提高病人的生活质量。Objective To investigate the clinical efficacy of capecitabine metronomic chemotherapy in the life-sustaining treatment of metastatic breast cancer in the elderly. Methods From December 2014 to December 2015,40 patients with metastatic breast cancer were randomly divided into metronomic chemotherapy group and conventional chemotherapy group,with 20 cases in each group. The metronomic chemotherapy group received low dose of capecitabine 500 mg,bid,sustained oral; The patients in the conventional chemotherapy group were treated with capecitabine 1250 mg,bid for 14 d,7 d off,with a course of 21 d. The clinical efficacy,side effects and quality of life were evaluated after two courses. Results There were no significant differences in the effective rate（ RR）（ 25. 0% vs30. 0%） and the control rate（ DCR）（ 90. 0% vs 85. 0%） between the metronomic chemotherapy group and the conventional chemotherapy group（ P〉0. 05）. There were no side effects of grade Ⅲ and Ⅳ in the metronomic chemotherapy group. The incidence rates of hand-foot syndrome（ 60. 0%）,myelosuppression（ 60. 0%） and gastrointestinal reactions（ 65. 0%） were significantly higher in the conventional chemotherapy group than those in the metronomic chemotherapy group（ P〈0. 05）. The improvement of life guality（ 90. 0%） in metronomic chemotherapy group was significantly better than that of the conventional chemotherapy group（ P〈0. 05）. Conclusions The clinical efficacy of capecitabine metronomic chemotherapy in the life-sustaining treatment of elderly patients with metastatic breast cancer is comparable to that of conventional dose maintenance therapy,and it can alleviate the adverse reaction of patients,and improve the quality of life.

关 键 词：卡培他滨 节拍化疗 转移性乳腺癌 维持治疗 

分 类 号：R737.9[医药卫生—肿瘤]