Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases  

作　　者：Audrey T.Medeiros Luigi Bubacco Jennifer R.Morgan 

机构地区：[1]The Eugene Bell Center for Regenerative Biology and Tissue Engineering,Marine Biological Laboratory [2]Department of Biology,University of Padova

出　　处：《Neural Regeneration Research》2018年第4期647-648,共2页中国神经再生研究（英文版）

基　　金：supported by a grant from National Institutes of Health(NINDS/NIA R01NS078165 to JRM);research funds from the Marine Biological Laboratory(to JRM);a research grant from Horizon 2020 Grant No.In Cure EU Joint Programme-JPND(to LB)

摘　　要：α-Synuclein causes synaptic pathologies in several neurodegenerative diseases：Parkinson’s disease（PD）is a neurodegenerative disease that impacts the lives of millions of people worldwide.A pathological hallmark of PD,as well as dementia with Lewy bodies（DLB）and several Alzheimer’s disease variants,is the appearanceof intracellular inclusions called Lewy bodies, which contain high levels of aggregated α-synuclein,α-Synuclein causes synaptic pathologies in several neurodegenerative diseases：Parkinson’s disease（PD）is a neurodegenerative disease that impacts the lives of millions of people worldwide.A pathological hallmark of PD,as well as dementia with Lewy bodies（DLB）and several Alzheimer’s disease variants,is the appearanceof intracellular inclusions called Lewy bodies, which contain high levels of aggregated α-synuclein,

关 键 词：synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases Impacts of increased 

分 类 号：R741[医药卫生—神经病学与精神病学]