氟西汀对肿瘤并发急性脑梗死后抑郁作用评价  

EVALUATION OF FLUOXETINE IN THE TREATMENT OF TUMOR PATIENTS WITH DEPRESSION AFTER ACUTE CEREBRAL INFARCTION

作　　者：王彦[1] 穆珊珊[1] 李伟[1] 张凤莲[1] 白鸽[1] 刘泽民[1] Wang Yan;Mu Shanshan;Li Wei(Tangshan People＇s Hospital , Tangshan 063000, Chin)

机构地区：[1]河北省唐山市人民医院神经内一科,063001

出　　处：《中国煤炭工业医学杂志》2018年第1期58-61,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生厅河北医学科学研究重点课题计划项目(编号:201204600)

摘　　要：目的分析氟西汀对肿瘤并发急性脑梗死后抑郁的临床治疗效果。方法选取该院2015年1月—2017年1月间收治的肿瘤并发急性脑梗死后抑郁患者50例,分为观察组和对照组,每组各25例。对照组进行神经内科常规治疗,观察组在对照组治疗基础上加用氟西汀,共治疗8周。治疗前,治疗2周、4周、8周后分别采用汉密顿抑郁量表(HAMD)、美国国立卫生研究院卒中量表(NIHSS)进行评分,评估患者的抑郁状态和神经功能缺损程度。结果治疗前二组间HAMD评分及NIHSS评分差异无统计学意义(P>0.05);治疗2周后二组间HAMD评分及NIHSS评分差异无统计学意义(P>0.05);治疗4周及8周后二组间HAMD量表评分及NIHSS评分差异显著,差异有统计学意义(P<0.05)。结论氟西汀能显著改善肿瘤并发急性脑梗死后患者的抑郁状态及神经功能缺损症状。Objective To analyze clinical therapeutic effect of fluoxetine in tumor patients complicated with acute depression after cerebral infarction.Methods Fifty cases of cancer patients with acute cerebral infarction who were treated in author′s hospital from January 2015 to January 2017 were randomly divided into observation group and control group,25 cases in each group.The control group was given conventional treatment in neurology department,and the observation group was treated with fluoxetine on the basis of the control group.The treatment lasted for 8 weeks.Before treatment and treatment for 2 weeks,4 weeks,8 weeks,we used the Hamilton Depression Scale（HAMD）,National Institutes of Health Stroke Scale（NIHSS）score to assess the therapeutic effect of fluoxetine.Results Before treatment,there was no significant difference in HAMD score and NIHSS score between the two groups（P〉0.05）;and also no significance differences 2 weeks after treatment（P〉0.05）;but there was significance differences between the two groups 4 weeks and 8 weeks after treatment HAMD score and NIHSS score（P〈0.05）.Conclusion Fluoxetine can significantly improve the depressive state of tumor patients complicated with acute cerebral infarction.

关 键 词：氟西汀 肿瘤并发急性脑梗死 抑郁 作用 

分 类 号：R730.6[医药卫生—肿瘤]