基于Weka平台的分类算法在启动子识别中的应用  

The application of classification algorithms in promoters' identification based on Weka platform

作　　者：蒋璐凯 JIANG Lukai(School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China)

机构地区：[1]哈尔滨工业大学计算机科学与技术学院,哈尔滨150001

出　　处：《智能计算机与应用》2018年第2期190-192,F0003,共4页Intelligent Computer and Applications

摘　　要：在"后基因组"时代,对于DNA功能元件的注释,尤其是启动子这类关键的调控元件的鉴定是进一步理解人类基因组繁杂调控网络的重要研究内容。本文基于高通量测序数据对细胞系H1-hesc中的基因启动子进行识别分类,利用数据挖掘软件Weka基于启动子组蛋白修饰特征建立分类模型,比较各分类算法性能优劣,以期应用最佳分类器在其它细胞系中识别分类启动子。The definition of DNA functional elements（ especially promoters） is an important research topic in understanding the regulatory network of human genome. This paper identifies types of gene promoters in H1-hesc cell line based on the high-throughput data and then builds classifiers between different types of promoters according to the data of histone modification feature.Finally,the paper compares four classifiers＇ performance and it is expected to apply the best model in the predicting and identifying promoters in other cell lines.

关 键 词：启动子 高通量测序 WEKA 分类算法 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]