小反刍兽疫病毒全基因组遗传进化分析  

Phylogenetic Analysis of the Whole Genome in Peste Des Petits Ruminants Virus

作　　者：王净[1] 王鹏[2] 王长顺 史冠旭 Wang Jing;Wang Peng;Wang Changshun;Shi Guanxu(College of Animal Science and Technology, Hebei North University, Zhangjiakou, 075131;College of Farming and Forestry Technology, Hebei North University, Zhangjiakou, 075131)

机构地区：[1]河北北方学院动物科技学院,张家口075131 [2]河北北方学院农林科技学院,张家口075131

出　　处：《基因组学与应用生物学》2018年第4期1393-1396,共4页Genomics and Applied Biology

基　　金：河北省科技计划项目[11230405D-1(2013)-4;14236602D-3(2014);14236602D-2(2015)];河北省畜牧兽医局科技项目[2015-1-05]共同资助

摘　　要：为了确定中国小反刍兽疫各毒株间的进化关系,本研究从Gen Bank下载世界各国PPRV全基因组序列,以生物信息学方法建立遗传进化树。搜集到13株PPRV全基因组序列,其中中国10株,印度3株,巴基斯坦0株。中国2013~2014年毒株在同一个分支,2014年北京毒株和同年份的其它毒株相比枝条最长,2015年新疆巴州毒株独立成一个小分支。2014~2015年每一个毒株和2013年新疆伊犁毒株相比,遗传距离都最近,最小值为0.001 1。2007~2008年毒株位于另一分支,2007年西藏两毒株间遗传距离为0.000 6。毒株间的遗传关系跟地理位置呈正相关。本研究揭示国内疫情传播路线可以为中国小反刍兽疫的防控提供线索和技术支持。In order to determine the evolutionary relationships among the strains of peste des petits ruminants virus in China, this study downloadedthe PPRV whole genome sequences from Gen Bank, and established phylogenetic trees by bioinformatics method. 13 strains of PPRV whole genome sequences were collected,including 10 strains in China, 3 strains in India and 0 strain in Pakistan. In China, the strains were clustered in one small branch in 20132014. Beijing strain was the longest compared with other strains in 2014.Chinaibex-XJBZ2015 was independent into a small branch. The genetic distance of each strain in 20142015 was closer than that of China-XJYL2013. The minimum value was 0.001 1. The strains were clustered in another branch in 20072008. The genetic distance was 0.000 6 between JF939201China-Tibet2007 and FJ905304China2007. The genetic relationship of the strains was positively correlated with geographical positions. This study would reveal the domestic epidemic spreading routes which might provide the potential clues and technical support for the prevention and control of peste des petits ruminants virus in China.

关 键 词：PPRV 全基因组 分子进化树 最大似然法 遗传距离 

分 类 号：S852.65[农业科学—基础兽医学]